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Antioxidant and DNA damage protecting potentials of polysaccharide extracted from Phellinus baumii using a delignification method

文献类型： 外文期刊

作者： Jin, Qun-li 1 ; Zhang, Zuo-fa 1 ; Lv, Guo-ying 1 ; Cai, Wei-ming 1 ; Cheng, Jun-wen 2 ; Wang, Jian-gong 3 ; Fan, Lei-f 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Hort, Hangzhou, Zhejiang, Peoples R China

2.Zhejiang Forestry Acad, Hangzhou, Zhejiang, Peoples R China

3.Chunan Sangdu Mushroom Specialized Farmers Cooper, Hangzhou, Zhejiang, Peoples R China

关键词： Phellinus baumill;Polysaccharide;Oxidative DNA damage;Acid-chlorite delignification

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

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收录情况： SCI

摘要： A delignification method was employed to extract the polysaccharide from the fruiting body of Phellinus baumii. The three parameters, processing temperature, ratio of water to raw material and amount of acetic acid every time were optimized using the Box-Behnken design. As a result, the optimal extraction conditions were: processing temperature 70.3 degrees C, ratio of water to raw material of 34.7 mL/g and amount of acetic acid of 0.32 mL every time. Under these conditions, the highest yield of polysaccharide (10.28%) was obtained. The main fraction (PPB-2) purified from PPB was composed of fucose, arabinose, galactose, glucose, xylose and mannose, while glucose was the predominant monosaccharide. PPB-2 exhibited noticeable antioxidant activity and strong protection against oxidative DNA damage. These findings implied that acid-chlorite delignification was a superior method to extract the polysaccharide from P. baumii and PPB-2 may be useful for cancer chemoprevention. (C) 2016 Elsevier Ltd. All rights reserved.

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