文献类型： 外文期刊
作者： Yang, Chi 1 ; Fu, Rao 1 ; Zhuang, Zhenhong 1 ; Wang, Shihua 1 ;
作者机构： 1.Fujian Agr & Forestry Univ, Key Lab Pathogen Fungi & Mycotoxins Fujian Prov, Key Lab Biopesticide & Chem Biol, Educ Minist,Sch Life Sci, Fuzhou 350002, Peoples R China
2.Fujian Acad Agr Sci, Inst Edible Fungi, Natl & Local Joint Engn Res Ctr Breeding & Cultiv, Fuzhou 350014, Peoples R China
关键词： Carbamyl phosphate synthetase I;Aflatoxin B-1;Hepatocarcinogenesis;Interacting protein
期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）
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年卷期：
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收录情况： SCI
摘要： Carbamyl phosphate synthetase 1 (CPS1) was down-regulated in hepatocellular carcinoma (HCC), as treated by aflatoxin B-1 (AFB(1)), a potent hepatocarcinogenesis mycotoxin. In this study, we firstly confirmed that AFB(1) down regulated the expression of CPS1 in a dose-dependent manner. At the meantime, both siRNA knock down of CPS1 and AFB(1), treatment inhibited cell proliferation, and induced cell apoptosis. To further analysis the function of CPS1, the interacting proteins of CPS1 were searched by Co-IP, and three interacting proteins including type II cytoskeletal 1 (KRT1), albumin (ALB), and ubiquitin C (UBC) were found. Both KRT1 and ALB were new interacting proteins for CPS1. Our further study showed that CPS1 was regulating interacted and colocalized with KRT1 and ALB, and the intensity correlation was changed by AFB1. KRT1, ALB and CPS1 were all reported to play an important role in differentiation and tissue specialization. These results may offer an increasing understand that CPS1 might have a function in differentiation. (C) 2016 Elsevier B.V. All rights reserved.
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