Efficient porcine reproductive and respiratory syndrome virus entry in MARC-145 cells requires EGFR-PI3K-AKT-LIMK1-COFILIN signaling pathway
文献类型： 外文期刊
作者： Wang, Rui 1 ; Wang, Xin 1 ; Wu, Jia-qiang 3 ; Ni, Bo 1 ; Wen, Li-bing 4 ; Huang, Li 1 ; Liao, Ying 2 ; Tong, Guang-zhi 2 ; D 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai, Peoples R China
3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing, Jiangsu, Peoples R China
关键词： Porcine reproductive and respiratory;syndrome virus;Entry;Epidermal growth factor receptor;Cofilin
期刊名称：VIRUS RESEARCH （ 影响因子：3.303； 五年影响因子：3.445 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Viruses have evolved diverse strategies to take over cellular machinery to facilitate their infection. In our studies presented here, we first demonstrated that Src kinase was involved in PRRSV entry in MARC-145 cells. Further studies demonstrated epidermal growth factor receptor (EGFR) was activated by the currently unknown mechanism(s) during PRRSV entry, which subsequently initiated EGFR downstream signal pathways, such as PI3K/AKT/LIMK1. Through these pathways, the virus entry signal was ultimately transferred to cofilin, which might regulate the actin fragmentation and reorganization to facilitate the virus penetration and cytoplasmic trafficking. (C) 2016 Elsevier B.V. All rights reserved.
- 相关文献
作者其他论文 更多>>
-
Knockdown of tyrosine hydroxylase gene affects larval survival, pupation and adult eclosion in Plagiodera versicolora
作者：Liu, Xiaolong;Wang, Xin;Zhang, Qi;Lu, Min;Ze, Longji;Zhang, Hainan
关键词：cuticle tanning; mortality;
Plagiodera versicolora ; RNA interference; tyrosine hydroxylase -
Biological delignification and anaerobic fermentation of wheat straw: A promising approach for sustainable utilization of crop straw bioresources
作者：Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Khan, Nazir Ahmad
关键词：Crop residues; Wheat straw; Lignin degradation; Anaerobic fermentation; Enzymatic hydrolysis; In vitro digestibility
-
Evaluation of growth stage and storage time on fermentation characteristics, microbial community structure, co-occurrence networks, and their functional shifts and pathogenic risk of fermented Italian ryegrass
作者：Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi;Wang, Siran;Ding, Chenglong;Tian, Jipeng;Cheng, Yunhui;Xu, Nengxiang;Zhang, Wenjie;Wang, Xin;Nazar, Mudasir;Liu, Beiyi
关键词：Growth stage; Fermentation product; Microbial community; Lolium multiflorum; Microbial risk
-
Effect of biological lignin depolymerization on rice straw enzymatic hydrolysis, anerobic fermentation characteristics and in vitro ruminal digestibility
作者：Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Nazar, Mudasir;Tian, Jipeng;Wang, Xin;Wang, Siran;Cheng, Yunhui;Zhang, Wenjie;Xu, Nengxiang;Liu, Beiyi;Ding, Chenglong;Khan, Nazir Ahmad
关键词：Rice straw; Lignin depolymerization; Ensiling; Enzymatic hydrolysis; In vitro digestibility
-
Comparative Analysis of Phenolic Acid Metabolites and Differential Genes Between Browning-Resistant and Browning-Sensitive luffa During the Commercial Fruit Stage
作者：Feng, Yingna;Gao, Shuai;Wang, Rui;Liu, Yeqiong;Yan, Zhiming;Fang, Yichen;Zhu, Simin;Wang, Yuanhua;Feng, Yingna;Wang, Rui;Yan, Zhiming;Wang, Yuanhua;Yong, Mingli;Feng, Cui;Ni, Weichen;Liu, Liwang
关键词：
luffa cylindrica ; transcriptome; metabolome; browning; gene expression -
A Study of Growth and Yield of Four Peanut Varieties with Rhizobia Inoculation under Field Conditions
作者：Ding, Bin;Feng, Mengshi;Wang, Rui;Chang, Lei;Jiang, Ying;Xie, Jixian;Tian, Da
关键词：Arachis hypogaea L.; rhizobia agent; root nodules; yield
-
A Scalable and Robust Chloroplast Genotyping Solution: Development and Application of SNP and InDel Markers in the Maize Chloroplast Genome
作者：Wang, Rui;Yang, Yang;Tian, Hongli;Yi, Hongmei;Xu, Liwen;Ge, Jianrong;Zhao, Yikun;Wang, Lu;Wang, Fengge;Lv, Yuanda;Zhou, Shiliang
关键词：chloroplast; SNP; InDel; high throughput; genotyping; maize
