Alleviation of cyclophosphamide-induced immunosuppression in mice by naturally acetylated hemicellulose from bamboo shavings
文献类型： 外文期刊
作者： Huang, Ju-qing 1 ; Pang, Mei-rong 1 ; Li, Guang-yu 3 ; Wang, Nan 1 ; Jin, Lu 1 ; Zhang, Ying 1 ;
作者机构： 1.Zhejiang Univ, Sch Biosyst Engn & Food Sci, Dept Food Sci & Nutr, Hangzhou 310058, Zhejiang, Peoples R China
2.Fujian Acad Agr Sci, Inst Agr Engn & Technol, Fuzhou, Peoples R China
3.Zhejiang Univ, Sch Publ Hlth, Hangzhou, Zhejiang, Peoples R China
关键词： Bamboo-shavings hemicellulose (BSH);naturally acetylated hemicellulose;alleviation;cyclophosphamide-induced immunosuppression;T-bet;GATA-3
期刊名称：FOOD AND AGRICULTURAL IMMUNOLOGY （ 影响因子：3.101； 五年影响因子：2.573 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： Bamboo-shavings hemicellulose (BSH) is a water-extractable hemicellulose isolated from steamed-exploded bamboo shavings. The present study investigated the protective potential of BSH against cyclophosphamide (CPA)-induced immunosuppression in mice. Mice were orally administered BSH once daily at the dose of 50, 100 or 200mg/kg body weight (BW) for 14 days, coupled with a hypodermic injection of CPA (70mg/kg BW/day) on days 4, 8 and 12. The results showed that 14 days of oral administration of BSH at a dose of 100 or 200mg/kg BW/day significantly accelerated the recoveries of serum hemolysin formation, phagocytic function of the reticuloendothelial system, splenocyte proliferation, splenic NK cell activity, secretion of splenic Th1/Th2 cytokines (IL-2, IL-12, TNF-, INF-/IL-4) together with mRNA expression of Th1/Th2 transcription factors (T-bet/GATA-3) in CPA-induced immunosuppressive mice. Our results demonstrated that BSH could ameliorate CPA-induced immunosuppression in mice and may potentially serve as a supportive therapy in conventional chemotherapy.
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