Bamboo shavings derived O-acetylated xylan alleviates loperamide-induced constipation in mice
文献类型： 外文期刊
作者： Huang, Juqing 1 ; Lin, Bin 1 ; Zhang, Ying 3 ; Xie, Zhenglu 4 ; Zheng, Yi 1 ; Wang, Qi 2 ; Xiao, Hang 2 ;
作者机构： 1.Fujian Acad Agr Sci, Inst Agr Engn, Fuzhou 350003, Peoples R China
2.Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA
3.Zhejiang Univ, Sch Biosyst Engn & Food Sci, Dept Food Sci & Nutr, Hangzhou 310058, Peoples R China
4.Fujian Agr & Forestry Univ, Jinshan Coll, Fuzhou 350002, Peoples R China
关键词： Constipation; Short-chain fatty acids; Gut microbiota; Transcriptome analysis
期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：10.723； 五年影响因子：9.964 ）
ISSN： 0144-8617
年卷期： 2022 年 276 卷
页码：
收录情况： SCI
摘要： BSH-1 is an O-acetylated xylan obtained from bamboo shavings. This study determined the protective effects of BSH-1 against loperamide (Lop)-induced constipation in mice. Mice received BSH-1 by gavage daily for 14 days. In constipated mice, BSH-1 significantly shortened the defecation time and raised the gastrointestinal (GI) transit rate, stool production, and cecal concentration of short-chain fatty acids (SCFAs). BSH-1 regulated the serum levels of gut hormones and neurotransmitters. BSH-1 also significantly altered the cecal microbiota of the constipated mice by increasing the abundance of potentially beneficial bacteria (e.g., Lactobacillus, Roseburia, and Bacteroidales_S24-7) and decreasing potentially pathogenic bacteria (e.g., Alloprevotella and Staphylococcus). Furthermore, colonic transcriptome analysis revealed that BSH-1 significantly reversed the expression changes of genes related to intestinal motility, water and ion transport, inflammation and cancer in constipated mice. Our findings indicated that BSH-1 effectively relieved Lop-induced constipation in mice and could be potentially used for constipation treatment.
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