Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-kappa B and MAPK pathways in macrophages
文献类型： 外文期刊
作者： Wang, Qi 1 ; Huang, Juqing 1 ; Zheng, Yafeng 2 ; Guan, Xuefang 1 ; Lai, Chenchun 1 ; Gao, Huiying 1 ; Ho, Chi-Tang 4 ; Lin, Bin 1 ;
作者机构： 1.Fujian Acad Agr Sci, Inst Agr Engn, Fuzhou 350003, Peoples R China
2.Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
3.Fujian Key Lab Agr Prod Food Proc, Fuzhou 350003, Peoples R China
4.Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA
关键词： Oolong tea; Selenium; Anti-inflammatory; NF-kappa B and MAPK pathways
期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：8.022； ）
ISSN：
年卷期： 2022 年 11 卷 3 期
页码：
收录情况： SCI
摘要： Both tea polyphenols and selenium (Se) have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation, which make Se-enriched oolong tea a promising beverage as an anti-inflammatory diet. The aim of this study is to investigate the anti-inflammatory effects of Se-enriched oolong tea extract (Se-TE) and underlying mechanism in lipopolysaccharide (LPS)-induced RAW264.7 cells. Se-TE treatments (50 and 150 mu g/mL) significantly suppressed the over-production of nitric oxide (NO) and prostaglandin E2 (PGE(2)) in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, Se-TEs also effectively inhibited the productions of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta). Furthermore, Se-TE could block mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappa B) signaling pathways through the inhibition of the phosphorylation of key proteins (I kappa B-alpha, p65, p38, ERK, and JNK) and the translocation of the p65 subunit into the nucleus. Collectively, our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases. (C) 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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