Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells
文献类型： 外文期刊
作者： Oliveira, Helder 1 ; Cai, Xiaoshuang 2 ; Zhang, Qian 2 ; de Freitas, Victor 1 ; Mateus, Nuno 1 ; He, Jingren 2 ; Ferna 1 ;
作者机构： 1.Univ Porto, Fac Sci, Dept Chem & Biochem, REQUIMTE,LAQV, P-4169007 Oporto, Portugal
2.Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Peoples R China
3.Hubei Collaborat Innovat Ctr Proc Agr Prod, Wuhan 430023, Peoples R China
4.Wuhan Polytech Univ Qual Cereals Oils & Foodstuff, Inspect & Test Ctr Proc, Wuhan 430023, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：5.396； 五年影响因子：5.534 ）
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收录情况： SCI
摘要： The gastrointestinal absorption of the main carotenoids present in Gardenia jasminoides Ellis, crocetin, crocin-1 and crocin-2, was assayed through transport studies on MKN-28 and Caco-2 cell lines. Overall, crocetin was the compound that presented the highest gastrointestinal transport efficiency. Additionally, and since after absorption crocins are metabolized into crocetin, the antiproliferative capacity of crocetin was assayed in MKN-28 (stomach), MCF-7 (breast) and Caco-2 (colon) cancer cell lines. The results point to an antiproliferative effect of crocetin on the three cell lines tested. Anti-inflammatory properties were also assayed. Overall, crocetin showed a potential involvement in the downregulation of IL-1 beta and TNF-alpha but not IL-6. Altogether, these results suggest that these compounds can have an important role against cancer proliferation, highlighting the importance of Gardenia jasminoides Ellis as a nutraceutical food source.
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