文献类型： 外文期刊
作者： Yu, Jianning 1 ; Yan, Leyan 1 ; Chen, Zhe 1 ; Li, Hui 1 ; Ying, Shijia 1 ; Zhu, Huanxi 1 ; Shi, Zhendan 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Anim Sci, Lab Anim Breeding & Reprod, Nanjing 210014, Jiangsu, Peoples R China
关键词： Chick embryo;Degeneration;Right ovary;Transcriptome sequencing
期刊名称：JOURNAL OF REPRODUCTION AND DEVELOPMENT （ 影响因子：2.214； 五年影响因子：2.221 ）
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收录情况： SCI
摘要： In asymmetric chick gonads, the left and right female gonads undergo distinct programs during development, generating a functional ovary on the left side only. Despite some progress being made in recent years, the mechanisms of molecular regulation remain incompletely understood, and little genomic information is available regarding the degeneration of the right ovary in the chick embryo testis. In this study, we performed transcriptome sequencing to investigate differentially expressed genes in the left and right ovaries and gene functions at two critical time points; embryonic days 6 (E6) and 10 (E10). Using high-throughput RNA-sequencing technologies, 539 and 1046 genes were identified as being significantly differentially expressed between 6R-VS-6L and 10R-VS-10L. Gene ontology analysis of the differentially expressed genes revealed enrichment in functional pathways. Among these, candidate genes associated with degeneration of the right ovary in the chick embryo were identified. Identification of a pathway involved in ovarian degeneration provides an important resource for the further study of its molecular mechanisms and functions.
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