Enhanced Expression of Serotonin Receptor 5-Hydroxytryptamine 2C is Associated with Increased Feather Damage in Dongxiang Blue-Shelled Layers
文献类型: 外文期刊
作者: Yao, Junfeng 1 ; Wang, Xiaoliang 1 ; Yan, Huangxiang 1 ; Cai, Xia 1 ; Wang, Min 2 ; Tu, Yingying 2 ; Yang, Changsuo 1 ;
作者机构: 1.Shanghai Acad Agr Sci, 2901 Beidi Rd, Shanghai 201106, Peoples R China
2.Natl Poultry Engn Res Ctr, Shanghai, Peoples R China
关键词: Chicken HTR2C;Feather condition;Receiving feather pecking;SNPs;Gene expression
期刊名称:BEHAVIOR GENETICS ( 影响因子:2.805; 五年影响因子:2.671 )
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年卷期:
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收录情况: SCI
摘要: The gene encoding the serotonin receptor 5-hydroxytraptamine 2C (HTR2C) has been implicated in behavioral phenotypes in a number of species. In previous studies, a mutation in the chicken HTR2C gene was found to be associated with feather condition, thereby suggesting a relationship between the gene and receiving feather pecking activity. The present study analyzed the chicken HTR2C gene at both the genomic make-up and expression level in Dongxiang blue-shelled layer. A significant association between the single nucleotide polymorphism (SNP) rs13640917 (C/T) and feather condition was confirmed in the Chinese local layer. Enhanced HTR2C gene expression (151.1-fold) that was associated with high feather damage indicated that the right cerebrum might be the critical region for HTR2C to participate in the regulation of receiving feather pecking behavior.
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