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Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice

文献类型： 外文期刊

作者： Zhao, Lei 1 ; Jiang, Yu 2 ; Ni, Yuxin 3 ; Zhang, Tianzhu 4 ; Duan, Cuicui 5 ; Huang, Cheng 5 ; Zhao, Yujuan 5 ; Gao, Lei; 1 ;

作者机构： 1.Changchun Univ Chinese Med, Sch Basic Med Sci, Changchun 130117, Jilin, Peoples R China

2.Northeast Normal Univ, High Sch, Changchun 130117, Jilin, Peoples R China

3.Jilin Univ, Sch & Hosp Stomatol, Dept Implantol, Changchun 130021, Jilin, Peoples R China

4.Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Jilin, Peoples R China

5.Jilin Acad Agr Sci, Inst Agrofood Technol, 1363 Sheng Tai St, Changchun 130033, Jilin, Peoples R China

关键词： Lactobacillus plantarum;Hepatoprotective;Anti-oxidation;Anti-inflammation;Intestinal barrier

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

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收录情况： SCI

摘要： The protective effects of L plantarum C88 against chronic alcohol-induced liver injury in mice were investigated. The pretreatment with L plantarum C88 significantly decreased the levels of alanine transaminase and aspartate aminotransferase in chronic alcohol-challenged mice. L plantarum C88 was also found to suppress the content of malondialdehyde (MDA) and enhance the activity of superoxide dismutase (SOD) in the liver, which are well-correlated with the downregulation of hepatic cytochrome P450 2E1 and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). Moreover, L plantarum C88 significantly abrogated the increased serum levels of TNF-alpha, IL-6, and IFN-gamma induced by ethanol. L plantarum C88 ameliorated gut leakiness by upregulating the expressions of tight junction proteins and suppressed the endotoxin-mediated inflammation by decreasing P38 phosphorylation and down-regulating NF-kappa B. These results demonstrate that L plantarum C88 efficiently protects against alcoholic chronic liver injury. (C) 2017 Elsevier Ltd. All rights reserved.

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