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Ameliorative effect of vitamin E on hepatic oxidative stress and hypoimmunity induced by high-fat diet in turbot (Scophthalmus maximus)

文献类型: 外文期刊

作者: Jia, Yudong 1 ; Jing, Qiqi 3 ; Niu, Huaxin 2 ; Huang, Bin 1 ;

作者机构: 1.Chinese Acad Fishery Sci, Qingdao Key Lab Marine Fish Breeding & Biotechnol, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

2.Inner Mongolia Univ Nationalities, Sch Anim Sci & Technol, Tongliao 028042, Peoples R China

3.Shandong Agr Univ, Coll Anim Sci & Vet Med, Tai An 271018, Shandong, Peoples R China

关键词: Vitamin E;High-fat diet;Growth;Oxidative stress;Nonspecific immunity;Turbot

期刊名称:FISH & SHELLFISH IMMUNOLOGY ( 影响因子:4.581; 五年影响因子:4.851 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: This study was conducted to examine the effects of vitamin E on growth performance, oxidative stress and non-specific immunity of turbot (Scophthalmus maximus) fed with high-fat diet. Results showed that high-fat diet significantly increased hepatosomatic index, viscerosomatic index, hepatic malondialdehyde level and decreased catalase and superoxide dismutase activities, whereas final weight, specific growth rate and survival rate remained unchanged. Meanwhile, nitro blue tetrazolium positive leucocytes of head kidney, respiratory burst activity in head-kidney macrophage, phagocytic index and serum lysozyme activity were significantly reduced after feeding with high-fat diet. Furthermore, fish fed with high-fat diet promoted higher expression of heat shock protein (hsp70, hsp90), and inhibited expression of complement component 3(c3) in the liver and tumor necrosis factor-alpha (tuf-alpha), interleukine 18 (il-beta)toll like receptor 22 (tlr-22) in the spleen and head-kidney, respectively. However, simultaneous supplementation with 480 mg kg(-1) vitamin E protected turbot against high-fat diet-induced hepatic oxidative stress, hypoimmunity through attenuating lipid peroxidation, renewing antioxidant enzymes activities and nonspecific immune responses, and modulating the expression of stress protein (hsp70, hsp90) and immune-related genes (c3, trtf-alpha, it-1 beta, tlr-22). In conclusion, the obtained results indicate the vitamin E as a wildly used functional feed additive contributes potentially to alleviate high-fat diet induced hepatic oxidative stress and hypoimmunity, maintain the health, and improve the broodstock management for turbot. (C) 2017 Elsevier Ltd. All rights reserved.

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