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Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069

文献类型： 外文期刊

作者： Yang, Cheng-Long 1 ; Wang, Yi-Shuang 1 ; Liu, Cheng-Li 1 ; Zeng, Ying-Jie 1 ; Cheng, Ping 1 ; Jiao, Rui-Hua 1 ; Bao, S 1 ;

作者机构： 1.Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

2.Nanjing Univ, St

关键词： alkaloid;strepchazolin;streptazolin;Streptomyces charteus;marine natural product;antimicrobial activity;acetylcholinesterase inhibitory activity

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

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收录情况： SCI

摘要： Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher's method. Compound 1 showed weak anti-Bacillus subtilis activity with the MIC value of 64.0 mu M, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC50 value of 50.6 mu M, while its diastereoisomer, Compound 2, is almost inactive.

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