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Tris(1,3-dichloro-2-propyl) phosphate disrupts axonal growth, cholinergic system and motor behavior in early life zebrafish

文献类型： 外文期刊

作者： Cheng, Rui 1 ; Jia, Yali 1 ; Dai, Lili 2 ; Liu, Chunsheng 1 ; Wang, Jianghua 1 ; Li, Guangyu 1 ; Yu, Liqin 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Beijing, Peoples R China

3.Collaborat Innovat Ctr Efficient & Hlth Prod Fish, Changde 415000, Hunan, Peoples R China

4.Hubei Prov Engn Lab Pond Aquaculture, Wuhan, Hubei, Peoples R China

关键词： TDCIPP;Zebrafish larvae;Motor behavior;Axonal growth;Cholinergic system

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.964； 五年影响因子：5.071 ）

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收录情况： SCI

摘要： Highlights?TDCIPP altered motor behaviors in zebrafish larvae.?TDCIPP decreased neuron-specific GFP expression in Tg (HuC-GFP) zebrafish larvae.?TDCIPP inhibited axonal growth of secondary motor neurons and altered expressions of genes related to axonal growth.?TDCIPP inhibited the cholinergic system in zebrafish larvae.AbstractTris(1,3-dichloro-2-propyl) phosphate (TDCIPP) could have neurotoxic effects and alter motor behaviors in zebrafish (Danio rerio) larvae, however, the underlying mechanisms are still unknown. In this study, zebrafish embryos were subjected to waterborne exposure of TDCIPP at 100, 300, 600, 900μg/L from 2 to 120-h post-fertilization (hpf). Behavioral measurements indicate that TDCIPP exposure significantly elevated spontaneous movement, and altered swimming behavior response of larvae to both light and dark stimulation. Interestingly, in accordance with these motor effects, TDCIPP significantly decreased expression of the neuron-specific GFP in transgenic (HuC-GFP) zebrafish larvae as well as decreased expression of the neural marker geneselavl3andngn1, inhibited the axonal growth of the secondary motoneurons and altered the expressions of axon-related genes (α1-tubulin,shhaandnetrin2) in zebrafish larvae. Furthermore, TDCIPP exposure at 900μg/L significantly increased the activity of acetylcholinesterase (AChE) enzyme, and decreased the total acetylcholine (ACh) concentration. Our data indicate that the alteration in motor neuron and inhibition of cholinergic system could together lead to the TDCIPP induced motor behavior alterations in zebrafish larvae.]]>

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