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Identification of bioactives from Astragalus chinensis L.f. and their antioxidant, anti-inflammatory and anti-proliferative effects

文献类型： 外文期刊

作者： Hu, Ting 1 ; Liu, Qi-Mei 2 ; He, Xiao-Wei 2 ; Huang, Fei 3 ; Zhang, Ming-Wei 3 ; Jiang, Jian-Guo 2 ;

作者机构： 1.Wuhan Inst Technol, Sch Chem Engn & Pharm, Wuhan 430205, Hubei, Peoples R China

2.South China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Guangdong, Peoples R China

3.Guangdong Acad Agr Sci, Sericultural & Agr Food Res Inst, Key Lab Funct Foods, Minist Agr,Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Guangdong, Peoples R China

关键词： Astragalus chinensis L.f.;Antioxidant;Antitumor;Anti-inflammatory;Formononetin;Calycosin

期刊名称：JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE （ 影响因子：2.701； 五年影响因子：3.574 ）

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收录情况： SCI

摘要： This work was designed to obtain the valuable compounds with antioxidant, anti-proliferative and anti-inflammatory activities from Astragalus chinensis. Ethyl acetate fraction obtained from A. chinensis L.f. had significant antioxidant, anti-proliferative and anti-inflammatory activities. Subsequently, five single compounds were separated and purified, which were identified as formononetin (1), rhamnocitrin (2), calycosin (3), beta-daucosterol (4), rhamnocitrin-3-O-beta-d-glucoside (5). The results displayed that formononetin and rhamnocitrin exhibited significant cytotoxicity actions against tumor cell lines. Calycosin exerted the strongest anti-inflammatory effect of inhibition effects on NO production in macrophages.

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