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A Glycopeptide from Agaricus balchaschensis Mitigates Cadmium Damage in Mice

文献类型： 外文期刊

作者： Yalimaimaiti, Nuerziya 1 ; Dong, Yongqiang 2 ; Jia, Peisong 1 ; Feng, Xiaobin 3 ; Luo, Ying 1 ; Hao, Jingzhe 1 ; Jia, Wenjie 1 ; Chen, Haoyu 1 ; Zhu, Qi 1 ; Liang, Zhihao 1 ; Luo, Cheng 1 ;

作者机构： 1.Xinjiang Acad Agr Sci, Inst Plant Protect, Lab Integrated Pest Management Crops Northwestern, Xinjiang Key Lab Agr Biosafety,Minist Agr & Rural, Urumqi 830091, Peoples R China

2.China Agr Univ, Coll Hort, Dept Vegetables, Lab Med & Edible Fungi, Beijing 100193, Peoples R China

3.Cang Zhou Acad Agr & Forestry Sci, Cangzhou 061000, Peoples R China

4.Chinese Acedmy Agr Sci, Inst Food Sci Technol Nutr & Hlth Cangzhou, Cangzhou 061000, Peoples R China

关键词： Agaricus balchaschensis; peptide-containing polysaccharide; structure

期刊名称：PROCESSES （ 影响因子：2.8； 五年影响因子：3.1 ）

ISSN：

年卷期： 2025 年 13 卷 1 期

页码：

收录情况： SCI

摘要： This study was aimed at extracting, characterizing, and exploring the detoxification activity of the peptide-containing polysaccharide from Agaricus balchaschensis. An anion adsorption fraction was acquired through hot water extraction. Its structure was analyzed, and the potential protective effect against cadmium-intoxicated mice was explored. Structural analysis revealed that the principal component of the peptide-containing polysaccharide of A. balchaschensis (ABPCP) is polysaccharide, which consists of glucose, mannose, galactose, and xylose, containing (1 -> 4)-linked alpha-D-glucan, (1 -> 3)-linked beta-D-Glcp, (1 -> 4)-linked beta-D-Glcp, (1 -> 6)-linked beta-D-Glcp, (1 -> 6)-linked beta-D-Manp, (1 -> 3)-linked beta-D-Galp, (1 -> 6)-linked beta-D-Galp, and (1 -> 4)-linked beta-D-xylan. The amino acid content of ABPCP is 11.747 mg/g. Threonine, serine, glutamate, glycine, alanine, cysteine, valine, methionine, lysine, and arginine were detected in ABPCP, among which the content of glutamate was the highest. The alleviating effect of ABPCP on cadmium poisoning in mice was investigated. ABPCP significantly reduced the cadmium content in serum and the heart, kidneys, and liver, which indicates that ABPCP could promote cadmium discharge. ABPCP also significantly decreased serum nitric oxide, endothelin-1, urea, uric acid, and serum creatinine, alleviating kidney and liver damage caused by cadmium. All these results manifest that ABPCP can lower the cadmium content in organs and alleviate the damage to kidneys and livers damaged by Cd.

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