Hypoglycemic Effect of Ethanol and Ethyl Acetate Extract of Phellinus baumii Fruiting Body in Streptozotocin-Induced Diabetic Mice
文献类型： 外文期刊
作者： Wang, Wen-Han 1 ; Wu, Fei-Hua; Yang, Yan 1 ; Wu, Na 1 ; Zhang, Jing-Song 1 ; Feng, Na 1 ; Tang, Chuan-Hong 2 ;
作者机构： 1.Shanghai Acad Agr Sci, Shanghai Key Lab Agr Genet & Breeding, Inst Edible Fungi,Natl Engn Res Ctr Edible Fungi, Minist Agr,Key Lab Appl Mycol Resources & Utiliza, Shanghai 201403, Peoples R China
2.Shanghai Acad Agr Sci, Shanghai Key Lab
期刊名称：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE （ 影响因子：2.629； 五年影响因子：2.845 ）
ISSN： 1741-427X
年卷期： 2015 年
页码：
收录情况： SCI
摘要： We investigated hypoglycemic effect of ethanol (EtOH) and ethyl acetate extract acetate (AcOEt) extracts in streptozotocin-(STZ-) induced diabetic mice. Our data showed the maximum inhibitory effect on the fasting plasma glucose (FPG) level was detected in STZ-induced diabetic mice administered with 400 g/kg AcOEt extract of P. baumii. A lower glycated albumin (GA) level and a higher insulin level were observed in 400 g/kg AcOEt and EtOH extract groups. Moreover, 400 g/kg AcOEt and EtOH extract exhibited a stronger effect on increasing size and cell number of islets. The insulin expression level of beta-cells and integrated optical density (IOD) value were significantly increased by the administration of 400 g/kg AcOEt and EtOH extracts. Taken together, AcOEt and EtOH extracts of P. baumii fruiting body exhibited considerable hypoglycemic effect on STZ-induced diabetic mice.
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