Cumulative health risk assessment of co-occurring mycotoxins. of deoxynivalenol and its acetyl derivatives in wheat and maize: Case study, Shanghai, China
文献类型： 外文期刊
作者： Han, Zheng 1 ; Nie, Dongxia 1 ; Ediage, Emmanuel Njumbe 2 ; Yang, Xianli 1 ; Wang, Jianhua 1 ; Chen, Bo 3 ; Li, Shugua 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Minist Agr, Lab Qual & Safety Risk Assessment Agroprod Shangh, Inst Agrofood Stand & Testing Technol, Shanghai 201403, Peoples R China
2.Univ Ghent, Fac Pharmaceut Sci, Lab Food Anal, B-9000 Ghent, Belgium
3.Fudan Univ, Sch Pub
关键词： Co-occurring mycotoxins;Concentration addition concept;Cumulative risk assessment;Probabilistic analysis
期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）
ISSN： 0278-6915
年卷期： 2014 年 74 卷
页码：
收录情况： SCI
摘要： Humans are naturally and frequently exposed to a multitude of mycotoxins, but health risk assessments are usually performed on individual mycotoxins, which may underestimate the total risks. In this study, we assessed for the first time the cumulative health risks of concomitant exposure via dietary intake (DI) to multiple mycotoxins, namely deoxynivalenol (DON) and its acetyl derivatives of 3-acetyldeoxynivalenol (3-ADON) and 15-acetyldeoxynivalenol (15-ADON), based on the concentration addition (CA) concept. A cross-sectional study was conducted in seven districts in Shanghai, China with 1269 participants and 330 wheat and maize samples analyzed. After probabilistic analysis using Monte Carlo simulation, the results showed no health risks to the population in Shanghai considering individual mycotoxins. However, if the cumulative health risks were calculated based on the combined consideration of DON with either 3-ADON or 15-ADON or both, the DI values in 95th percentile were up to 1087 ng/kg body weight/day, exceeding the Provisional Maximum Tolerable Daily Intake (PMTDI) of 1000 ng/kg body weight/day and hence representing potential health risks to the population in Shanghai. The integrated study proposed here could be a model strategy for cumulative health risk assessment on the co-occurring hazards in the fields of food safety combined with environmental contaminants. (C) 2014 Elsevier Ltd. All rights reserved.
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