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Porcine alpha interferon inhibit Japanese encephalitis virus replication by different ISGs in vitro

文献类型： 外文期刊

作者： Liu, Ke 2 ; Liao, Xuewen 1 ; Zhou, Bin 2 ; Yao, Huijuan 1 ; Fan, Shengchao 1 ; Chen, Puyan 2 ; Miao, Denian 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai 201106, Peoples R China

2.Nanjing Agr Univ, Key Lab Anim Dis Diag & Immunol, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China

3.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

关键词： Porcine alpha interferon;Japanese encephalitis virus;IFN-stimulated genes

期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）

ISSN： 0034-5288

年卷期： 2013 年 95 卷 3 期

页码：

收录情况： SCI

摘要： Japanese encephalitis virus (JEV) causes serious zoonosis in South Asia, Southeast Asia and other areas. Pigs are an important reservoir for this virus in nature. The treatment of JEV infection in pigs is important for controlling the prevalence of JEV in humans and economic losses in pig farming. In this study, we selected a high activity porcine alpha-interferon to inhibit JEV replication in porcine kidney cell lines (PK-15). Alpha interferon exhibited high antiviral activity against JEV; the expression of three interferon-stimulated genes (ISGs), ISG15, Mx2 and OAS L, increased significantly after interferon treatment. Furthermore, we verified the anti-JEV effect of these ISGs by RNAi and overexpression. Mx2 and OAS L exhibited strong anti-JEV effects in PK-15 cells. Based on these novel results, alpha interferon (IFN-alpha) should be considered to be a potential drug against JEV in pigs. (C) 2013 Elsevier Ltd. All rights reserved.

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