文献类型： 外文期刊
作者： Xia, Dong 1 ; Parvizi, Nahid 2 ; Zhou, Yuchuan 3 ; Xu, Kesi 1 ; Jiang, Hui 1 ; Li, Rongjie 1 ; Hang, Yiqiong 1 ; Lu, Yang 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai 201106, Peoples R China
2.Inst Farm Anim Genet FLI, Dept Funct Genom & Bioregulat, Mariensee, Germany
3.Chinese Acad Sci, Shanghai Key Lab Mol Androl, Shanghai, Peoples R China
关键词： fenvalerate;intergenerational action;methylation;reproductive function;mice
期刊名称：REPRODUCTIVE SCIENCES （ 影响因子：3.06； 五年影响因子：3.109 ）
ISSN： 1933-7191
年卷期： 2013 年 20 卷 11 期
页码：
收录情况： SCI
摘要： Fenvalerate (Fen), a synthetic pyrethroid insecticide, has been shown to have adverse effects on male reproductive system. Thus, the aim of the present study was to elucidate whether these adverse effects are passed from exposed male mice to their offspring. Adult male mice received Fen (10 mg/kg) daily for 30 days and mated with untreated females to produce offspring. Fenvalerate significantly changed the methylation status of angiotensin I-converting enzyme (Ace), forkhead box O3 (Foxo3a), huntingtin-associated protein 1 (Hap1), nuclear receptor subfamily 3 (Nr3c2), promyelocytic leukemia (Pml), and Prostaglandin F2 receptor negative regulator (Ptgfrn) genes in paternal mice sperm genomic DNA. Further, Fen significantly increased sperm abnormalities; serum testosterone and estradiol-17 ss level in adult male (F0) and their male offspring (F1). Further, paternal Fen treatment significantly increased the length of estrous cycle, serum estradiol-17 ss concentration in estrus, and progesterone levels in diestrus in female offspring (F1). These findings suggest that adverse effects of paternal Fen exposure on reproductive functions can be seen not only in treated males (F0) but also in their offsprings.
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