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The potential mechanism of Bursal-derived BPP-II on the antibody production and avian pre-B cell

文献类型： 外文期刊

作者： Feng, Xiuli 1 ; Cao, Ruibing 1 ; Zhou, Bin 1 ; Liu, Qingtao; Liu, Ke 1 ; Liu, Xiaodong 1 ; Zhang, Yuanpeng 1 ; Gu, Jin 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Chinas Dept Agr, Div Key Lab Anim Dis Diag & Immunol, Nanjing 210095, Jiangsu, Peoples R China

关键词： BPP-II;Antibody production;Gene microarray;Homologous recombination

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN： 0264-410X

年卷期： 2013 年 31 卷 11 期

页码：

收录情况： SCI

摘要： The bursa of Fabricius is critical for the normal development of the B lymphocytes responsible for antibody production. However, the mechanism of the bursal-derived bioactive factor on B cell development is little reported. In this paper, chicks were immunized with BPP-II and AIV vaccine or AIV antigen, and antibody and IL-4 production were detected. The results showed that BPP-II played strongly inducing roles on the humoral immune responses. To investigate the gene expression at transcriptional level, avian preB lymphocyte DT40 cells were treated with BPP-II, and were analyzed with the gene microarray. The results proved that BPP-II treatment regulated 11 pathways, in which homologous recombination is a vital mechanism which is involved in antibody Ig gene conversion and diversification during B cell development. These results suggested Bursal-derived biological active factor BPP-II might be involved in the antibody production processes and B cell development, which is vital to the humoral central immune organ, the bursa of Fabricius. (C) 2012 Elsevier Ltd. All rights reserved.

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