A 90-Day Dietary Toxicity Study of Genetically Modified Rice T1C-1 Expressing Cry1C Protein in Sprague Dawley Rats
文献类型： 外文期刊
作者： Tang, Xueming 1 ; Han, Fangting 3 ; Zhao, Kai 1 ; Xu, Yan 3 ; Wu, Xiao 1 ; Wang, Jinbin 1 ; Jiang, Lingxi 1 ; Shi, Wei 3 ;
作者机构： 1.Shanghai Acad Agr Sci, Biotechnol Res Inst, Shanghai, Peoples R China
2.Shanghai Acad Agr Sci, Key Lab Agr Genet & Breeding, Shanghai, Peoples R China
3.Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai, Peoples R China
期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）
ISSN： 1932-6203
年卷期： 2012 年 7 卷 12 期
页码：
收录情况： SCI
摘要： In a 90-day study, Sprague Dawley rats were fed transgenic T1C-1 rice expressing Cry1C protein and were compared with rats fed non-transgenic parental rice Minghui 63 and rats fed a basal diet. No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed, and standard hematological and biochemical parameters were compared. A few of these parameters were found to be significantly different, but were within the normal reference intervals for rats of this breed and age, and were thus not considered to be treatment-related. Following sacrifice, a large number of organs were weighed, and macroscopic and histopathological examinations were performed with no changes reported. The aim of this study was to use a known animal model to determine the safety of the genetically modified (GM) rice T1C-1. The results showed no adverse or toxic effects due to T1C-1 rice when tested in this 90-day study.
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