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Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells

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文献类型：外文期刊

作者： Gao, F. ² ; Tang, Q. ³ ; Yang, P. ² ; Fang, Y. ² ; Li, W. ⁴ ; Wu, Y. ¹ ;

作者机构： 1.Shanghai Jiao Tong Univ, Sch Med, Key Lab Cell Differentiat & Apoptosis, Dept Pathophysiol,Natl Minist Educ, Shanghai 200025, Peoples R China

2.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp Affiliated 3, Shanghai 200025, Peoples R China

3.Shanghai Acad Agr Sci SAAS, Inst Edible Fungi, Shanghai, Peoples R China

4.Wenzhou Med Coll, Sch Life Sci, Zhejiang Prov Key Lab Med Genet, Wenzhou, Zhejiang, Peoples R China

关键词： Oridonin;apoptosis;ROS;leukemia;differentiation

期刊名称：INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY （影响因子：2.877；五年影响因子：2.921 ）

ISSN： 1751-5521

年卷期： 2010 年 32 卷 1 期

页码：

收录情况： SCI

摘要： We investigated the effects of oridonin (Ori), a diterpenoid isolated from Rabdosia rubescens, on apoptosis and differentiation of all-trans-retinoic acid (ATRA)-sensitive (NB4) and ATRA-resistant (NB4-R1) cells. The results showed that reactive oxygen species initiates Ori-induced apoptosis. In addition, we found that neither Ori nor ATRA (10 nm) alone induced marked cell differentiation, while co-treatment of these two compounds can induce differentiation of NB4 and NB4-R1 cells which was accompanied by increased RAR alpha, C/EBP epsilon or C/EBP beta. This is the first report to show that RAR alpha could be accumulated by Ori which may be useful as a probe to investigate the mechanism of RAR alpha catabolism. These results suggest that Ori is a potential candidate for acute promyelocytic leukemia cancer therapy.

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