Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China
文献类型: 外文期刊
作者: Li Ya-fei 1 ; Jiang Hong-xia 1 ; Xiang Rong 2 ; Sun Na 3 ; Zhang Ya-nan 1 ; Zhao Li-qing 1 ; Gu Peng 1 ; Wang Li-qiao 1 ; Ze 1 ;
作者机构: 1.South China Agr Univ, Coll Vet Med, Lab Vet Pharmacol, Guangzhou 510642, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangdong Open Lab Vet Publ Hlth, Guangzhou 510640, Guangdong, Peoples R China
3.Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun 130112, Peoples R China
关键词: Riemerella anatipestifer;resistance;efflux;CCCP;PA beta N
期刊名称:JOURNAL OF INTEGRATIVE AGRICULTURE ( 影响因子:2.848; 五年影响因子:2.979 )
ISSN: 2095-3119
年卷期: 2016 年 15 卷 4 期
页码:
收录情况: SCI
摘要: The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum efflux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Phe-Arg-beta-naphthylamide (PA beta N), on the contribution of minimum inhibitory concentrations of amikacin, streptomycin, chloramphenicol, tetracycline, ceftriaxone, ceftazidime, nalidixic acid, levofloxacin, enrofloxacin, as well as ciprofloxacin against 69 clinical R. anatipestifer isolates were investigated. We first reported that the two efflux pump inhibitors could restore the antimicrobial susceptibility of R. anatipestifer isolates. It is suggested that active efflux system is possible to be linked with the development of resistance in R. anatipestifer isolates.
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