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A preliminary risk assessment of potential exposure to naturally occurring estrogens from Beijing (China) market milk products

文献类型： 外文期刊

作者： Chen, Chen 1 ; Mi, Xiaoxia 1 ; Yuan, Yuwei 2 ; Chen, Gang 1 ; Ren, Li 3 ; Wang, Kaiqiang 1 ; Zhu, Dan 1 ; Qian, Yongzhong 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Qual & Safety, Beijing 100081, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Qual & Standard Agroprod, Key Lab Pesticide Residue Detect, Minist Agr, Hangzhou 310021, Zhejiang, Peoples R China

3.Air Force Gen Hosp, Dept Pathol, Beijing 100142, Peoples R China

关键词： Estrogens;Milk products;LC MS/MS;Dietary intakes;Risk assessment

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2014 年 71 卷

页码：

收录情况： SCI

摘要： This study was conducted to determine the occurrence of the natural steroid hormones estrone (El), 17 alpha-estradiol (alpha E2), 17 beta-estradiol (beta E2) and estriol (E3) in 38 commercial milk samples obtained from markets in Beijing, China. Liquid Chromatography coupled with tandem mass spectrometry (LC-MS/MS) was employed to determine estrogens levels. The concentrations of El, alpha E2, beta E2 and E3 in different milk products varied from 0-146.12 ng/L, 0-70.12 ng/L, 0-31.85 ng/L to 0-2.18 ng/L, respectively. We compared exposures to estrogens through milk consumption with acceptable daily intakes (ADIs) and threshold for toxicological concern (TTC) to determine whether estrogen intakes from milk consumption are larger or smaller than the toxicity-based benchmarks. The combined margin of safety MOS (MOST) for total estrogens are about 72-99, 118-161, 539-1104, for 2-4, 4-7 year-old residential children, and adults, respectively. The lowest MOST for children of 2-4 years old result from comparing total of estrogens with the lowest TTC value (0.15 mu g/person/day) (MOS = 3.5). The MOS values suggest that the individual and total estrogens that may present in milk are not causing a health risk for the local residents, including young children. (C) 2014 Elsevier Ltd. All rights reserved.

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