文献类型： 外文期刊
作者： Zheng, Yi 1 ; Zha, Xia 1 ; Zhang, Bei 1 ; Elsabagh, Mabrouk 3 ; Wang, Hongrong 1 ; Wang, Mengzhi 1 ; Zhang, Hao 1 ;
作者机构： 1.Yangzhou Univ, Lab Metab Manipulat Herbivorous Anim Nutr, Coll Anim Sci & Technol, Yangzhou 225009, Peoples R China
2.Yangzhou Univ, Joint Int Res Lab Agr & Agriprod Safety, Minist Educ China, Yangzhou, Peoples R China
3.Nigde Omer Halisdemir Univ, Fac Agr Sci & Technol, Dept Anim Prod & Technol, Nigde, Turkiye
4.Kafrelsheikh Univ, Dept Nutr & Clin Nutr, Fac Vet Med, Kafrelsheikh, Egypt; Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China
关键词： endoplasmic reticulum stress; autophagy; trophoblast; preeclampsia; intrauterine growth retardation
期刊名称：BIOLOGY OF REPRODUCTION （ 影响因子：3.6； 五年影响因子：4.2 ）
ISSN： 0006-3363
年卷期： 2024 年
页码：
收录情况： SCI
摘要： The endoplasmic reticulum is a complex and dynamic organelle that initiates unfolded protein response and endoplasmic reticulum stress in response to the accumulation of unfolded or misfolded proteins within its lumen. Autophagy is a paramount intracellular degradation system that facilitates the transportation of proteins, cytoplasmic components, and organelles to lysosomes for degradation and recycling. Preeclampsia and intrauterine growth retardation are two common complications of pregnancy associated with abnormal trophoblast differentiation and placental dysfunctions and have a major impact on fetal development and maternal health. The intricate interplay between endoplasmic reticulum stress, and autophagy and their impact on pregnancy outcomes, through mediating trophoblast differentiation and placental development, has been highlighted in various reports. Autophagy controls trophoblast regulation through a variety of gene expressions and signaling pathways while excessive endoplasmic reticulum stress triggers downstream apoptotic signaling, culminating in trophoblast apoptosis. This comprehensive review delves into the intricacies of placental development and explores the underlying mechanisms of preeclampsia and intrauterine growth retardation. In addition, this review will elucidate the molecular mechanisms of endoplasmic reticulum stress and autophagy, both individually and in their interplay, in mediating placental development and trophoblast differentiation, particularly highlighting their roles in preeclampsia and intrauterine growth retardation development. This research seeks to the interplay between endoplasmic reticulum stress and impaired autophagy in the placental trophoderm, offering novel insights into their contribution to pregnancy complications. [GRAPHICS] .
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