Digestion characteristics of jujube polysaccharide and its regulatory effect on intestinal microbiota and metabolites during in vitro fermentation
文献类型： 外文期刊
作者： Ji, Xiaolong 1 ; Chen, Jin 1 ; Li, Ziran 1 ; Meng, Yan 3 ; Li, Xiaoqiong 4 ;
作者机构： 1.Zhengzhou Univ Light Ind, Coll Food & Bioengn, Zhengzhou 450001, Peoples R China
2.Natl & Local Joint Engn Res Ctr Cereal Based Foods, Zhengzhou 450001, Peoples R China
3.Hubei Univ Chinese Med, Sch Pharm, Wuhan 430065, Peoples R China
4.Zhejiang Acad Agr Sci, Inst Food Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China
关键词： In vitro fermentation; Jujube polysaccharide; Gut microbiota; Metabolites
期刊名称：LWT-FOOD SCIENCE AND TECHNOLOGY （ 影响因子：6.6； 五年影响因子：6.9 ）
ISSN： 0023-6438
年卷期： 2024 年 210 卷
页码：
收录情况： SCI
摘要： Polysaccharides, a vital bioactive component of jujube (Ziziphus jujuba Mill.), have shown considerable promise in enhancing studies on and the development of functional foods. In this paper, an in vitro digestive fermentation model was developed to explore the unique structural features, fermentation kinetics in feces, and effects on the gut microbiome and metabolic by-products of jujube polysaccharide (PZMP2). The results demonstrated that the digested PZMP2 was predominantly comprised of seven monosaccharides, with a relative molecular mass of 61.8 kDa. The overall concentration of total sugar, total reduction sugar and pH decreased while SCFAs increased significantly due to the utilization of PZMP2 after 48 h of fermentation. Furthermore, PZMP2 has been shown to stimulate the expansion of beneficial gut bacteria, particularly Firmicutes, Phascolarctobacterium, and Lachnoclostridium, while concurrently suppressing the growth of detrimental microbial species, such as Proteobacteria, Klebsiella, and Escherichia-Shigella. Bioinformatics analysis showed that PZMP2 could regulate host health through bile acid and amino acid metabolisms. In conclusion, PZMP2 functions as an intrinsic prebiotic factor that influences the equilibrium of intestinal microbiota and alters the profile of metabolic byproducts, and hence exerts a significant influence on the intestinal microbial environment.
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