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Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde

文献类型: 外文期刊

作者: Li, Bin 1 ; Shan, Chang-Lin 1 ; Zhou, Qing 1 ; Fang, Yuan 3 ; Wang, Yang-Li 2 ; Xu, Fei 4 ; Han, Li-Rong 5 ; Ibrahim, Muh 1 ;

作者机构: 1.Zhejiang Univ, Inst Biotechnol, State Key Lab Rice Biol, Hangzhou 310058, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou 310021, Zhejiang, Peoples R China

3.Zhejiang Normal Univ, Coll Chem & Life Sci, Jinhua 321004, Peoples R China

4.Zhejiang Acad Agr Sci, Inst Digital Agr, Hangzhou 310021, Zhejiang, Peoples R China

5.Northwe

关键词: antibacterial activity;characterization;chitosan;cross-link;glutaraldehyde

期刊名称:MARINE DRUGS ( 影响因子:5.118; 五年影响因子:5.951 )

ISSN: 1660-3397

年卷期: 2013 年 11 卷 5 期

页码:

收录情况: SCI

摘要: This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Furthermore, high temperature treated cross-linked chitosan-glutaraldehyde showed strong antibacterial activity against the selected strain 0901 although the inhibitory effects varied with different temperatures. In addition, physical-chemical and structural characterization revealed that the cross-linking of chitosan with glutaraldehyde resulted in a rougher surface morphology, a characteristic Fourier transform infrared (FTIR) band at 1559 cm(-1), a specific X-ray diffraction peak centered at 2 theta = 15 degrees, a lower contents of carbon, hydrogen and nitrogen, and a higher stability of glucose units compared to chitosan based on scanning electron microscopic observation, FTIR spectra, X-ray diffraction pattern, as well as elemental and thermo gravimetric analysis. Overall, this study indicated that cross-linked chitosan-glutaraldehyde is promising to be developed as a new antibacterial drug.

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