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Protective effect of Enterococcus faecium against ethanol-induced gastric injury via extracellular vesicles

文献类型： 外文期刊

作者： Luo, Meiying 1 ; Sun, Junhang 1 ; Li, Suqian 1 ; Wei, Limin 2 ; Sun, Ruiping 3 ; Feng, Xin 1 ; Zhang, Huihua 1 ; Chen, Ting 4 ; Xi, Qianyun 4 ; Zhang, Yongliang 4 ; Qi, Qien 1 ;

作者机构： 1.Foshan Univ, Sch Life Sci & Engn, Foshan, Peoples R China

2.Hainan Acad Agr Sci, Sanya Inst, Hainan Expt Anim Res Ctr, Sanya, Peoples R China

3.Inst Anim Sci & Vet Med, Hainan Acad Agr Sci, Haikou, Peoples R China

4.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Anim Nutr Control, Guangzhou, Peoples R China

关键词： Enterococcus faecium; extracellular vesicles; gastric injury; anti-inflammatory; anti-oxidative

期刊名称：MICROBIOLOGY SPECTRUM （ 影响因子：3.7； 五年影响因子：5.9 ）

ISSN： 2165-0497

年卷期： 2024 年 12 卷 4 期

页码：

收录情况： SCI

摘要： Recently, Enterococcus has been shown to have gastric protective functions, and the mechanisms by which Enterococcus modulates gastric function are still being investigated. Herein, we investigated how Enterococcus faecium (Efm) and E. faecium-derived extracellular vesicles (EVs) (EfmEVs) exert protective effect against ethanol-induced gastric injury by investigating the effect of EfmEVs on gastric mucosal ulcer scoring, histological lesion, mucosal glycoprotein production, acidity, anti-oxidative function, and inflammatory responses in rat. Pretreatment with Efm showed significant reduction of ethanol-induced gastric injury, as evidenced by the lowering of ulcer index, histological lesion, gastric pH, and inflammatory responses and the enhancement of mucosal glycoprotein production and anti-oxidative function. Further functional studies on three bioactive components [inactivated Efm, EfmEVs (EVs), and EV-free supernatants] of the bacterial culture showed that EVs are mostly responsible for the gastroprotective effect. Moreover, EV secretion is beneficial for the gastroprotective effect of Efm. Hence, EVs mediated the protective effect of Efm against ethanol-induced gastric injury by lowering inflammatory responses and enhancing anti-oxidative function and may be a potent anti-inflammatory and anti-oxidative strategy to alleviate hyperinflammatory gastrointestinal tract conditions.IMPORTANCEThis study indicated that Enterococcus faecium provided a protective effect against rat gastric injury, which involved improvement of the mucosal glycoprotein production, anti-oxidative function, and inflammatory responses. Furthermore, we confirmed that three bioactive components (inactivated Efm, extracellular vesicles, and EV-free supernatants) of E. faecium culture also contributed to the gastroprotective effect. Importantly, E. faecium-derived EVs showed an effective impact for the gastroprotective effect.

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