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Antidiabetic effects of cinnamon oil in diabetic KK-A(y) mice

文献类型： 外文期刊

作者： Ping, Hua 1 ; Zhang, Guijun 3 ; Ren, Guixing 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China

2.Beijing Res Ctr Agrifood Testing & Farmland Monit, Beijing 100097, Peoples R China

3.Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing 100102, Peoples R China

关键词： Cinnamon oil;Blood glucose;KK-A(y) mice

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2010 年 48 卷 8-9 期

页码：

收录情况： SCI

摘要： The hypoglycemic effect of cinnamon oil (CO) in a type 2 diabetic animal model (KK-A(y) mice) was studied. The main component of CO was cinnamaldehyde, and other nineteen components were also determined. CO was administrated at doses of 25, 50 and 100 mg/kg for 35 days. It was found that fasting blood glucose concentration was significantly decreased (P < 0.05) with the 100 mg/kg group (P < 0.01) the most efficient compared with the diabetic control group. In addition, there was significant decrease in plasma C-peptide, serum triglyceride, total cholesterol and blood urea nitrogen levels while serum high density lipoprotein (HDL)-cholesterol levels were significantly increased after 35 days. Meanwhile, glucose tolerance was improved, and the immunoreactive of pancreatic islets beta-cells was promoted. These results suggest that CO had a regulative role in blood glucose level and lipids, and improved the function of pancreatic islets. Cinnamon oil may be useful in the treatment of type 2 diabetes mellitus. (C) 2010 Elsevier Ltd. All rights reserved.

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