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Anti-skin aging effects of mulberry fruit extracts: In vitro and in vivo evaluations of the anti-glycation and antioxidant activities

文献类型： 外文期刊

作者： Zhang, Lijun 1 ; Chen, Qirong 2 ; Chen, Zhang 2 ; He, Taoping 2 ; Yu, Mengjie 1 ; Zhang, Yehui 1 ; Nan, Haijun 3 ; Huang, Qingrong 4 ; Zhao, Tiantian 1 ;

作者机构： 1.Minist Agr & Rural Affairs, Guangdong Acad Agr Sci, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc,Sericulture & Agri, Guangzhou 510610, Guangdong, Peoples R China

2.Guangzhou Coobase Biotechnol Co Ltd, Guangzhou 511493, Guangdong, Peoples R China

3.Guangdong Pharmaceut Univ, Sch Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China

4.Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

关键词： Mulberry fruit extract; AGEs; Oxidative stress; Anti-glycation; Anti -skin aging

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2024 年 112 卷

页码：

收录情况： SCI

摘要： In this study, we investigated the bioactive compounds extracted from air-dried mulberry fruit (DMF), mulberry fruit juice (MFJ), and mulberry fruit pomace (MFP). We examined the effects of extracts from DMF, MFJ, and MFP on advanced glycation end-products (AGEs). The in vitro results showed significant inhibition of AGEs both in the fructose-BSA and MGO-BSA models. The results of compositional analysis showed that the phenolic content was partially positively correlated with their antioxidant capacity. Additionally, we investigated the potential of MFP extracts to improve MGO-induced aging-related deficits in HaCaT cells. Furthermore, the in vivo trial results showed that both DMF-W (with water extraction) and DMF-P (with Pectinex (R) XXL extraction) significantly increased the moisture, HA and HYP contents in the skin of mice, reduced the levels of AGEs, and improved the oxidative stress damage in aging mice. Additionally, DMF-P showed a better anti-skin aging effect.

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