Mechanisms of immune responses in juvenile Acanthopagrus latus to Aeromonas hydrophila infection revealed by multi-tissue transcriptomic analysis
文献类型： 外文期刊
作者： Fan, Hong-Di 1 ; Liu, Min 2 ; Zhao, Yuan-Ming 1 ; Wang, Xu 3 ; Lin, Jia 1 ; Zhu, Qing 4 ; Huang, Wen 5 ; Wang, Jiang-Hai 1 ;
作者机构： 1.Sun Yat Sen Univ, Sch Marine Sci, Guangdong Prov Key Lab Marine Resources & Coastal, Zhuhai 519082, Peoples R China
2.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Peoples R China
3.Guangzhou Enenta Chemotech Co Ltd, Guangzhou 510635, Peoples R China
4.Southern Marine Sci & Engn Guangdong Lab Guangzhou, Guangzhou 511458, Peoples R China
5.Guangdong Acad Agr Sci, Inst Anim Sci, Collaborat Innovat Ctr Aquat Sci, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China
关键词： Acanthopagrus latus; Aeromonas hydrophila; Transcriptome analysis; Immune responses; Inflammation
期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：4.0 ）
ISSN： 2352-5134
年卷期： 2025 年 41 卷
页码：
收录情况： SCI
摘要： Yellowfin seabream (Acanthopagrus latus) is an economically important species extensively cultivated along the southeast coastal sea of China. This species is frequently afflicted by infections from Aeromonas hydrophila, a pathogen that causes widespread morbidity and mortality. In this study, an infection model was established by administering an intraperitoneal injection of A. hydrophila into yellowfin seabream. Subsequent observations and histopathological assessments revealed considerable damages of multi-tissues after the infection. Biochemical serum assays and measurements of immune-related enzyme activities indicated evident metabolic disturbances and inflammatory pathways in the affected fish. RNA sequencing analysis identified 1615 differentially expressed genes (DEGs) in the liver and 2578 DEGs in the intestine. KEGG mapping revealed significantly regulated pathways, including the C-type lectin receptor signaling pathway and MAPK signaling pathway in the liver, and calcium signaling pathway and cytokine-cytokine receptor interaction in the intestine. A protein-protein interaction network was also constructed for pivotal genes, such as cxcr4b and cd44b, which may play crucial roles in the immune and inflammatory pathways of yellowfin seabream. The transcriptomic results were further corroborated by quantitative real-time PCR tests of some specific genes. These novel data have revealed the immune-related pathways and key regulatory genes activated by A. hydrophila infection and may offer a valuable insight into the immune response mechanisms of yellowfin seabream.
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