Ilex latifolia Improves the Anti-Tumor Effectiveness of Rapamycin Against Breast Cancer In Vitro and In Vivo
文献类型： 外文期刊
作者： Ren, Zhengnan 1 ; Wu, Yikuan 2 ; Guo, Xiaoying 3 ; Tian, Haizhi 4 ; Ou, Hongjing 1 ; Xiong, Zihan 1 ; Xiao, Yu 1 ; Xiao, Longquan 1 ; Li, Jing 1 ; Wu, Haibo 5 ; Wang, Xinhui 1 ;
作者机构： 1.Chengdu Univ, Coll Food & Biol Engn, Chengdu 610106, Peoples R China
2.Jiangnan Univ, Inst Sci & Technol, Wuxi 214122, Peoples R China
3.Sichuan Kelun Pharmaceut Co Ltd, Chengdu 610599, Peoples R China
4.Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China
5.Xinjiang Acad Agr Sci, Turpan Inst Agr Sci, Turpan 838099, Peoples R China
关键词：
期刊名称：FOODS （ 影响因子：5.1； 五年影响因子：5.6 ）
ISSN：
年卷期： 2025 年 14 卷 9 期
页码：
收录情况： SCI
摘要： Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide. Although the mTOR inhibitor rapamycin exhibits notable anti-tumor activity, its clinical application is limited by metabolic side effects, particularly dyslipidemia. This study aimed to investigate the potential of Ilex latifolia (I. latifolia, large-leaf kudingcha), a traditional Chinese tea known for its lipid-lowering properties, to enhance the therapeutic efficacy of rapamycin in breast cancer. The combined effects of I. latifolia and low-dose rapamycin on tumor cell proliferation, cell cycle progression, apoptosis, and inflammation were assessed in four breast cancer cell lines and a murine breast cancer model. While low-dose I. latifolia alone exhibited limited anti-tumor activity, its combination with low-dose rapamycin synergistically inhibited tumor proliferation, induced cell cycle arrest, promoted apoptosis, and reduced inflammation in vitro. In vivo, dietary supplementation with I. latifolia mitigated rapamycin-induced lipid disturbances, reduced tumor growth, enhanced apoptosis, and alleviated inflammation in tumor tissues. These findings highlight I. latifolia as a promising dietary adjunct to rapamycin, providing a safer and more effective combinatorial strategy for breast cancer treatment.
- 相关文献
作者其他论文 更多>>
-
Structural characteristics of Brassica rapa L. Polysaccharide and its bioactivity on alcoholic liver injury
作者：Xu, Xin;Yang, Xinxin;Wang, Meng;Chen, Caiyue;Liu, Jiameng;Zheng, Jiahuan;Fan, Bei;Wang, Fengzhong;Sun, Jing;Xu, Xin;Chen, Caiyue;Zhu, Jingrong;Li, Jing;Fan, Bei;Wang, Fengzhong
关键词：Brassica rapa; Polysaccharide; Extraction process; Hepatoprotective activity
-
Characterization of a short-term processing technology of black garlic with low 5-HMF content
作者：Liu, Jun;Li, Jing;Ge, Shihao;Fu, Xiaoyu;Zhu, Jiamin;Wang, Mengnan;Wang, Yanrong;Huang, Xiaoxiao;Tu, Yixian;Xing, Jun;Ma, Chao;Liu, Yun-Guo;Qin, Xinzheng
关键词：Antioxidant capacity; Allicin; Browning degree; Key flavor compounds; S-Allyl-L-cysteine
-
Comparative transcriptome profiling suggests the role of phytohormones in leaf stalk-stem angle in melon ( Cucumis melo L.)
作者：Mao, Jiancai;Wang, Haojie;Li, Junhua;Yang, Junyan;Zhang, Yongbing;Wu, Haibo;Melon, Hami
关键词：Melon; Leaf stalk-stem angle; Comparative transcriptome; Phytohormone
-
Effect of Different Harvesting Dates on Tea Quality of Five Mulberry Varieties in Turpan City
作者：Guo, Hongmei;Liang, Ju;Zhao, Long;Li, Haifeng;Aisikae, Maitiniyazi;SU, Hanming;Wu, Haibo;Jun, Tan;Ren, Hongsong
关键词：Turpan; Morus nigra leaves; harvest date; principal component analysis
-
Transcriptomic Analysis of Salicylic Acid Promoting Seed Germination of Melon under Salt Stress
作者：Yan, Miao;Mao, Jiancai;Wu, Ting;Xiong, Tao;Wu, Haibo;Hu, Guozhi;Huang, Quansheng
关键词：Cucumis melo; salicylic acid; salt stress; transcriptome; differential genes
-
Comparative analysis of volatile compounds in thirty nine melon cultivars by headspace solid-phase microextraction and gas chromatography-mass spectrometry
作者：Shi, Jianda;Xiong, Mu;Bie, Zhilong;Huang, Yuan;Shi, Jianda;Xiong, Mu;Bie, Zhilong;Huang, Yuan;Wu, Haibo;Chen, Jihao;Zhou, Bo;Fu, Xiaofa;Chen, Yanjun;Wang, Hui;Li, Liangliang
关键词：Aroma volatiles; Cucumis melo; Fruit quality; HS-SPME-GC-MS
-
Transcriptome analysis clarified genes involved in resistance to Phytophthora capsici in melon
作者：Wang, Pingyong;Zhao, Guangwei;He, Yuhua;Kong, Weihu;Zhang, Jian;Liu, Shuimiao;Liu, Mengli;Hu, Keyun;Liu, Lifeng;Xu, Yongyang;Xu, Zhihong;Wu, Haibo
关键词：
