Salvianolic Acid B Alleviates LPS-Induced Spleen Injury by Remodeling Redox Status and Suppressing NLRP3 Inflammasome
文献类型： 外文期刊
作者： Wang, Hao 1 ; Dou, Xiao 3 ; Wang, Ruixue 3 ; Jiang, Yuxin 1 ; Zhang, Jinsong 1 ; Qiao, Xianjuan 3 ; Liu, Yingjun 3 ; Zhang, Hao 4 ; Lai, Chenhuan 1 ; Chen, Yanan 1 ; Yong, Qiang 1 ;
作者机构： 1.Nanjing Forestry Univ, Natl Key Lab Dev & Utilizat Forest Food Resources, Nanjing 210037, Peoples R China
2.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Prod Engn, Minist Agr & Rural Affairs, Nanjing 210014, Peoples R China
3.Shandong Prov Forestry Protect & Dev Serv Ctr, Jinan 250014, Peoples R China
4.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China
关键词： salvianolic acid B; spleen injury; redox status; NLRP3 inflammasome; mitochondria
期刊名称：ANTIOXIDANTS （ 影响因子：6.6； 五年影响因子：7.3 ）
ISSN：
年卷期： 2025 年 14 卷 7 期
页码：
收录情况： SCI
摘要： Background: The spleen is the primary reservoir of immune cells in mammals. Diverse stimuli can disrupt spleen homeostasis, resulting in spleen injury and immune dysfunction. This study employed a porcine model to assess the therapeutic potential of salvianolic acid B (SAB) against lipopolysaccharide (LPS)-induced splenic injury. Methods: Seventy-two male weanling piglets were randomly assigned to one of four groups: CON-SS, SAB-SS, CON-LPS, and SAB-LPS. The CON-SS and CON-LPS groups received a basal diet, while SAB-SS and SAB-LPS groups received a SAB-supplemented diet. After 14 d, the CON-SS and SAB-SS groups received an intraperitoneal injection of sterile saline, whereas the CON-LPS and SAB-LPS groups were injected with LPS. Blood and spleen tissues were harvested 6 h post-injection for biochemical analysis. Results: LPS induced systemic immune disorders in piglets, as evidenced by increased immune organ indices and decreased white blood cell, lymphocyte, and basophil counts in blood (p < 0.05). LPS also caused histoarchitectural disruption, cell apoptosis, oxidative stress, and inflammation in the spleen (p < 0.05). Conversely, SAB improved splenic histopathology and reduced splenic apoptosis and pro-inflammatory mediators in piglets (p < 0.05). SAB significantly mitigated peroxidation accumulation by facilitating the nuclear translocation of nuclear factor erythroid 2-related factor 2 and strengthening the antioxidant system, and inhibited nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome activation (p < 0.05). Mechanistically, SAB attenuated LPS-induced splenic oxidative stress and NLRP3 inflammasome activation by restoring mitochondrial structure and function (p < 0.05). Conclusions: This research unveils that SAB alleviates LPS-induced spleen disorder by reinforcing antioxidant system and suppressing NLRP3 inflammasome, highlighting SAB's potential as a prospective therapeutic agent for spleen disorders.
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