文献类型： 外文期刊
作者： Dong, Xing 1 ; Zhang, Zhen 1 ; Meng, Shunlong 4 ; Pan, Chenyuan 3 ; Yang, Ming 3 ; Wu, Xiangyang 1 ; Yang, Liuqing 2 ; Xu 1 ;
作者机构： 1.Jiangsu Univ, Inst Environm Hlth & Ecol Secur, Sch Environm & Safety Engn, Zhenjiang 212013, Peoples R China
2.Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Peoples R China
3.Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China
4.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China
5.CAFS, Key Lab Fishery Ecoenvironm Assessment & Resource, Wuxi 214081, Peoples R China
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：7.963； 五年影响因子：7.842 ）
ISSN： 0048-9697
年卷期： 2018 年 610 卷
页码：
收录情况： SCI
摘要： Transgenerational effects of environmental pollutants on humans and animals are complex. Thus, we used zebrafish to evaluate the effects of parental whole-life cycle exposure to bisphenol A and its analogs (bisphenol S and F) on offspring innate immunity. At adulthood, offspring were examined with/without continued chemicals treatment until 72 h post-fertilization (hpf). To measure offspring immune function, larvae at 72 hpf were expose for 24 h with/without the viral mimic polyinosinic-cytidylic acid (Poly I:C) or the bacterial mimic Pam3Cys-Ser-Lys4 (PAM3CSK4). Data show modified immunity in offspring. Specifically, lysozyme activity was significantly induced in F1 larvae and respiratory burst response and oxidative defense genes were inhibited. Genes of the innate immune system including Toll-like receptors and their downstream molecules and inflammatory cytokines were significantly down-regulated, whereas matrix metalloproteinases were up-regulated in larvae. In addition, recombination-activating genes in the immature adaptive immune system were significantly reduced. Thus, immune defense is diminished by exposing parental generations of zebrafish to environmentally relevant concentration of bisphenols and this suggests that fish chronically exposed to bisphenols in the wild may be vulnerable to pathogens. (C) 2017 Elsevier B.V. All rights reserved.
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