文献类型： 外文期刊
作者： Zhang, Linbao 1 ; Sun, Wei 1 ; Zhang, Zhe 1 ; Chen, Haigang 1 ; Jia, Xiaoping 1 ; Cai, Wengui 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Minist Agr, Sci Observing & Expt Stn South China Sea Fishery, Guangzhou 510300, Guangdong, Peoples R China; Chinese Acad Fishery Sci, Key Lab Fishery Ecol & Environm, Guangzhou 510300, Guangdong, Peoples R China; Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Guangzhou 510300, Guangdong, Peoples R China
关键词： Triazophos;Perna viridis;Metabolomics;Gender-specific responses
期刊名称：MARINE POLLUTION BULLETIN （ 影响因子：5.553； 五年影响因子：5.907 ）
ISSN： 0025-326X
年卷期： 2017 年 123 卷 1-2 期
页码：
收录情况： SCI
摘要： Triazophos, as a lipophilic organophosphate pesticide, displays higher bioaccumulation in the gonads of shellfish. To study the reproductive toxicity of triazophos, we applied metabolomics to characterize the gender specific metabolic responses in mussel Perna viridis exposed to triazophos. Metabolites were differently altered by triazophos in ovaries of mussel at different concentrations and time intervals, while basically similar metabolic response patterns were observed in male mussels at the two tested concentrations after exposure for 24 and 48 h. The significant changes of metabolites in ovaries of mussel exhibited the disturbances in energy metabolism and osmotic regulation, while in male samples triazophos only affected the energy metabolism. Moreover, glycine, sn-glycero-3-phosphocholine, ethanol, aspartate, etc. exhibited consistent variation tendency in both male and female individuals. While the changes of homarine, betaine, taurine, hypotaurine, malonate, beta-alanine, succinate, and choline showed obviously gender-specific responses. Overall, this study confirmed the gender-specific responses in gonad of P. viridis to triazophos exposure.
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