Simple and cost-effective determination of ciprofloxacin hydrochloride by electrical micro-titration
文献类型： 外文期刊
作者： Zhang, Xu-Zhi 1 ; Huang, Meng-Shi 1 ; Yang, Qian-Qian 1 ; Ding, Dong-Sheng 1 ; Zhao, Jun 1 ; Yang, Wen-Rong 3 ; Qu, Ke 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Qingdao Natl Lab Marine Sci & Technol, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
2.Shanghai Ocean Univ, Coll Marine Sci, Shanghai 201306, Peoples R China
3.Deakin Univ, Sch Life & Environm Sci, Geelong, Vic 3217, Australia
关键词： Ciprofloxacin hydrochloride;Determination;Micro-titration;Capacitively coupled contactless;conductivity detector;Pharmaceutical analysis
期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：6.779； 五年影响因子：4.558 ）
ISSN： 1001-8417
年卷期： 2017 年 28 卷 7 期
页码：
收录情况： SCI
摘要： By employing an electrical micro-titration system, in which a capacitively coupled contactless conductivity detector ((CD)-D-4) was used to monitor the reaction process in real time, herein a novel method for determining ciprofloxacin hydrochloride (CIPHCI) was developed for the first time. Mode 1: Standard CIPHCI solutions at different concentrations were loaded into reaction cells, respectively, and were titrated with standard Ag+. Upon the titration, the formation of a precipitate alters the number of ions in the solution, raising the change of conductivity, which was monitored by a special (CD)-D-4 to construct a titration curve. The endpoint of the titration was located from the peak of the curve. Between the elapsed time and the initial concentration of titrand, a linear relationship was established over the range of 2.0-8.0 mmol/L. Mode 2: Standard Fe3+ took the place of Ag+, and was used as titrant to recognize ciprofloxacin contributed to the formation of complexation, which also resulting a change of solution conductivity. Under optimized conditions, a working range of 1.0-5.0 mmol/L CIPHCI was found. Because the reaction solutions were isolated from the working electrodes, this pioneer work shows significant simplicity and cost-effectiveness, by eliminating the requirements for detector exchange/renewal between different measurements, and by involving no auxiliary chemicals. Both of the two approaches were applied successfully to determine CIPHCI in tablet samples. And the results were in good agreement with those obtained by reference method. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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