Pharmacokinetics of difloxacin in olive flounder Paralichthys olivaceus at two water temperatures
文献类型： 外文期刊
作者： Sun, M. 1 ; Li, J. 1 ; Gai, C. L. 1 ; Chang, Z. Q. 1 ; Li, J. T. 1 ; Zhao, F. Z. 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Minist Agr, Key Lab Sustainable Dev Marine Fisheries, Qingdao 266071, Peoples R China
2.Ocean Univ China, Fishery Coll, Qingdao, Peoples R China
3.Mariculture Inst Shandong Prov, Qingdao, Peoples R China
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）
ISSN： 0140-7783
年卷期： 2014 年 37 卷 2 期
页码：
收录情况： SCI
摘要： In this study, the pharmacokinetics profiles of difloxacin in the olive flounder (Paralichthys olivaceus) were investigated following intravenous and oral administration (10mg/kg BW) at 14 and 22 degrees C water temperatures. Plasma and tissue samples (muscle, liver, and kidney) were analyzed using an HPLC method. The results showed that the plasma concentration-time data for difloxacin were described commendably by two-compartment open model at the two water temperatures. The absorption half-life (t(1/2ka)) of difloxacin after oral administration were 2.08 and 1.10h at 14 and 22 degrees C, respectively; whereas the elimination half-life (t(1/2)) was 4.41 and 2.38h, respectively. The muscle concentration of 1.35 +/- 0.19g/g was observed at 9h at 14 degrees C, and 2.11 +/- 0.33g/g at 6h at 22 degrees C, respectively. For liver, the peak concentration of difloxacin 2.43 +/- 0.30g/g occurred at 6h at 14 degrees C, which was lower than the 3.34 +/- 0.24g/g peak that occurred at 4h at 22 degrees C. The calculated bioavailability of difloxacin was 68.07% at 22 degrees C, which was higher than the 53.43% calculated for 14 degrees C. After intravenous administration, the t(1/2) were 4.79 and 2.81h at 14 and 22 degrees C, respectively. The results indicate that the peak concentrations in muscle and liver at 14 degrees C are approximately half of those achieved at 22 degrees C. However, the C-max in kidney at 14 and 22 degrees C were similar. The V-d values were 1.20 and 1.75L/kg at 14 and 22 degrees C, respectively. These data indicated that both temperature and drug administration had significant effects on the elimination of difloxacin, and lower temperature or oral administration resulted in lower elimination.
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