ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway
文献类型: 外文期刊
作者: Liu, Jia 1 ; Ma, Leina 1 ; Chen, Xiao 1 ; Wang, Jianxun 1 ; Yu, Tao 1 ; Gong, Ying 1 ; Ma, Aiguo 1 ; Zheng, Lanhong 3 ; Lian 1 ;
作者机构: 1.Qingdao Univ, Coll Med, 38 Dengzhou Rd, Qingdao 266021, Peoples R China
2.Qingdao Univ, Affiliated Hosp, Qingdao 266003, Peoples R China
3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, 106 Nanjing Rd, Qingdao 266071, Peoples R China
关键词: Oleanolic acid;Apoptosis;ERK;Nrf2
期刊名称:TUMOR BIOLOGY ( 影响因子:3.65; 五年影响因子:3.445 )
ISSN: 1010-4283
年卷期: 2016 年 37 卷 6 期
页码:
收录情况: SCI
摘要: Oleanolic acid (OA) is a natural triterpenoid that is widely distributed in edible and medicinal plants. OA exerts anti-tumor activity on a wide range of cancer cells primarily through inducing apoptosis. Dysregulated ERK signaling is closely complicated in the biology of cancer, such as metastasis, proliferation, and survival, and it can be activated by various stimuli. In this study, we found that OA induced the activation of ERK in cancer cells. ERK activation compromised the apoptosis induced by OA. Blocking ERK activation by U0126 or siRNAs was able to potentiate the pro-apoptotic activity of OA on cancer cells. OA was shown to promote ERK-dependent Nrf2 expression in cancer cells, and in turn, Nrf2 expression was able to suppress OA-induced ROS generation. Blockade of Nrf2 expression was able to increase ROS levels and apoptotic death in cancer cells. In conclusion, we provided evidences that ERK activation is a mechanism underlying the resistance of cancer cells to OA-induced apoptosis and targeting ERK is a promising strategy to enhance the anti-tumor efficacy of OA.
- 相关文献
作者其他论文 更多>>
-
Combined ATAC-seq, RNA-seq, and GWAS analysis reveals glycogen metabolism regulatory network in Jinjiang oyster (Crassostrea ariakensis)
作者:Wu, Biao;Chen, Xi;Wang, Zhen-Yuan;Wang, Yan;Shao, Chang-Wei;Zhou, Li-Qing;Sun, Xiu-Jun;Liu, Zhi-Hong;Wu, Biao;Chen, Xi;Shao, Chang-Wei;Zhou, Li-Qing;Sun, Xiu-Jun;Liu, Zhi-Hong;Hu, Jie;Xu, Da-You;Guo, Hao-Bing;Fan, Guang-Yi;Wang, Zhen-Yuan;Xu, Da-You;Shao, Chang-Wei;Yu, Tao;Wang, Xiao-Mei;Zheng, Yan-Xin;Fan, Guang-Yi
关键词:Crassostrea ariakensis; Glycogen; Transcriptome; ATAC; GWAS
-
Combined ATAC-seq, RNA-seq, and GWAS analysis reveals glycogen metabolism regulatory network in Jinjiang oyster (Crassostrea ariakensis)
作者:Wu, Biao;Chen, Xi;Wang, Zhen-Yuan;Wang, Yan;Shao, Chang-Wei;Zhou, Li-Qing;Sun, Xiu-Jun;Liu, Zhi-Hong;Wu, Biao;Chen, Xi;Shao, Chang-Wei;Zhou, Li-Qing;Sun, Xiu-Jun;Liu, Zhi-Hong;Hu, Jie;Xu, Da-You;Guo, Hao-Bing;Fan, Guang-Yi;Wang, Zhen-Yuan;Yu, Tao;Wang, Xiao-Mei;Zheng, Yan-Xin;Fan, Guang-Yi
关键词:Crassostrea ariakensis; Glycogen; Transcriptome; ATAC; GWAS
-
Population genetics analysis of the black rockfish Sebastes schlegelii in Northern China based on 2b-RAD simplified genome sequencing
作者:Cao, Wei;Zhang, Mingyi;Wu, Nan;Han, Haiying;Zhong, Rujie;Yu, Tao;Ren, Liqun;Zhao, Chunnuan;Li, Bo;Zheng, Yanxin;Wu, Nan;Zhong, Rujie;Wang, Xiaomei
关键词:
-
Comprehensive analysis on the regulation of differentially expressed of mRNA and ncRNA in different ovarian stages of ark shell Scapharca broughtonii
作者:Wang, Wenjing;Wu, Biao;Liu, Zhihong;Sun, Xiujun;Zhou, Liqing;Wang, Wenjing;Wu, Biao;Liu, Zhihong;Sun, Xiujun;Zhou, Liqing;Xu, Wandong;Yu, Tao;Zheng, Yanxin;Zhang, Shihao
关键词:Ovarian development; Non-coding RNA; Sex steroid hormones; CeRNA; Scapharca broughtonii
-
Aminotransferase Class I and II Gene Family in the Jinjiang Oyster (Crassostrea ariakensis): Genomewide Identification, Phylogenetic Analysis and Expression Profiles after Salinity Stress
作者:Ge, Guangyu;Liu, Zhihong;Zhou, Liqing;Sun, Xiujun;Li, Zhuanzhuan;Ge, Guangyu;Liu, Zhihong;Zhou, Liqing;Sun, Xiujun;Li, Zhuanzhuan;Liu, Zhihong;Zhou, Liqing;Sun, Xiujun;Li, Zhuanzhuan;Yu, Tao;Zheng, Yanxin
关键词:Crassostrea ariakensis; aminotransferase class I and II gene family; high-salt stress; expression pattern
-
Molecular characterization and functional analysis of a mollusk Rel homologous gene
作者:Chen, Jiwen;Ma, Jilv;Cui, Jie;Dong, Juan;Qu, Yifan;Lu, Xiuqi;Wang, Anhao;Huang, Baoyu;Wang, Xiaotong;Zhang, Guoguang;Yu, Tao;Zheng, Yanxin;Cai, Shuai;Huang, Baoyu;Wang, Xiaotong
关键词:Scallop; Innate immunity; Rel; NF -KB; IKB
-
Molecular characterization of myosin heavy chain and its involvement in muscle growth and development in the Yesso scallop Patinopecten yessoensis
作者:Yang, Yumin;Zhou, Liqing;Wu, Biao;Liu, Zhihong;Sun, Xiujun;Yang, Yumin;Yu, Tao;Zheng, Yanxin;Sun, Xiujun
关键词:Scallop; Adductor muscle; Muscle development; Myosin heavy chain; Whole -mount in situ hybridization