Rare Carbon-Bridged Citrinin Dimers from the Starfish-Derived Symbiotic Fungus Penicillium sp. GGF16-1-2
文献类型： 外文期刊
作者： Fan, Hao 1 ; Shi, Zhi-Mian 1 ; Lei, Yan-Hu 1 ; Si-Tu, Mei-Xia 1 ; Zhou, Feng-Guo 1 ; Feng, Chan 1 ; Wei, Xia 1 ; Shao, Xue-Hua 2 ; Chen, Yang 1 ; Zhang, Cui-Xian 1 ;
作者机构： 1.Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China
2.Guangdong Acad Agr Sci, Inst Fruit Tree Res, Key Lab South Subtrop Fruit Biol & Genet Resource, Guangdong Prov Key Lab Trop & Subtrop Fruit Tree, Guangzhou 510640, Peoples R China
关键词： starfish-derived fungus; Penicillium sp; citrinin dimers; antifungal activities; cytotoxic activities; protein-protein interaction network
期刊名称：MARINE DRUGS （ 影响因子：6.085； 五年影响因子：6.044 ）
ISSN：
年卷期： 2022 年 20 卷 7 期
页码：
收录情况： SCI
摘要： Four novel, rare carbon-bridged citrinin dimers, namely dicitrinones G-J (1-4), and five known analogs (5-9) were isolated from the starfish-derived fungus Penicillium sp. GGF 16-1-2. Their structures were elucidated by extensive spectroscopic analysis and quantum chemical calculations. Compounds 1-9 exhibited strong antifungal activities against Colletotrichum gloeosporioides with LD50 values from 0.61 mu g/mL to 16.14 mu g/mL. Meanwhile, all compounds were evaluated for their cytotoxic activities against human pancreatic cancer BXPC-3 and PANC-1 cell lines; as a result, compound 1 showed more significant cytotoxicities than the positive control against both cell lines. In addition, based on the analyses of the protein-protein interaction (PPI) network and Western blot, 1 could induce apoptosis by activating caspase 3 proteins (CASP3).
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