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THE PROTECTION OF GLYCYRRHIZA POLYSACCHARIDE ON 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN INDUCED JIAN CARP (CYPRINUS CARPIO VAR.JIAN) LIVER INJURY USING PRECISION-CUT LIVER SLICES

文献类型： 外文期刊

作者： Du, Jin-Liang 1 ; Cao, Li-Ping 1 ; Jia, Rui 3 ; Yin, Guo-Jun 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Minist Agr, Key Lab Freshwater Fisheries & Germplasm Resource, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China

2.Chinese Acad Fishery Sci, Int Joint Res Lab Fish Immunopharmacol, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China

3.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China

关键词： 2,3,7,8-tetrachlorodibenzo-p-dioxin;Precision-Cut Liver Slices;Glycyrrhiza polysaccharide;Aryl hydrocarbon (AhR2);Aryl hydrocarbon receptor nuclear translocator (ARNT2);Cytochrome P4501A (CYP1A)

期刊名称：FRESENIUS ENVIRONMENTAL BULLETIN （ 影响因子：0.489； 五年影响因子：0.479 ）

ISSN： 1018-4619

年卷期： 2016 年 25 卷 6 期

页码：

收录情况： SCI

摘要： Exposure to 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) represents a potential health risk and hepatotoxicity. The aim of this study was to evaluate the protective effects of Glycyrrhiza polysaccharide (GPS) against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced hepatotoxicity in Jian carp using Precision-Cut Liver Slices (PCLS). In this study, PCLS were divided into six groups, five treatment groups (pretreatment group, post-treatment group, pre and post-treatment group, TCDD group, GPS control group), and one blank control group, GPS (0.2, 0.4 and 0.8 mg mL(-1)) was added to the PCLS before (pretreatment), after (post-treatment) and both before and after (pre- and post-treatment) the incubation of the PCLS with TCDD at 0.3 lig L-1 in the culture medium. The results showed, after PCLS treated with GPS, it was indicated that pre and post-treatment group had the best effect on relieving TCDD damage, it could significantly inhibited the elevation of glutamate pyruvate transaminase (GPT), glutamate oxalate transaminase (GOT), lactate dehydrogenase (LDH), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and immunoglobulin M(IgM), and significantly increased the level of superoxide dismutase (SOD) and glutathione S-transferase (GST). GPS can also reduce the expression of AhR2, ARNT2, CYP1A mRNA in different degrees. The present findings might provide new insight into the development of therapeutic and preventive approaches of TCDD toxicity.

  • 相关文献

[1]THE PROTECTION OF GLYCYRRHIZA POLYSACCHARIDE ON 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN INDUCED RAN CARP (CYPRINUS CARPIO VAR.JIAN) LIVER INJURY USING PRECISION-CUT LIVER SLICES. Du, Jin-Liang,Cao, Li-Ping,Yin, Guo-Jun,Du, Jin-Liang,Cao, Li-Ping,Yin, Guo-Jun,Jia, Rui,Yin, Guo-Jun. 2016

[2]Anti-inflammatory and hepatoprotective effects of glycyrrhetinic acid on CCl4-induced damage in precision-cut liver slices from Jian carp (Cyprinus carpio var. jian) through inhibition of the nf-kB pathway. Cao, Liping,Ding, Weidong,Jia, Rui,Du, Jingliang,Wang, Tao,Zhang, Chunyun,Gu, Zhengyan,Yin, Guojun,Cao, Liping,Ding, Weidong,Jia, Rui,Du, Jingliang,Wang, Tao,Zhang, Chunyun,Gu, Zhengyan,Yin, Guojun.

[3]Protective effect of Ganoderma lucidum polysaccharide against carbon tetrachloride-induced hepatic damage in precision-cut carp liver slices. Liu, Yingjuan,Zhang, Chunyun,Yin, Guojun,Du, Jinliang,Jia, Rui,Cao, Liping,Xu, Pao,Yin, Guojun,Du, Jinliang,Jia, Rui,Cao, Liping,Xu, Pao,Yin, Guojun,Jeney, Galina,Teraoka, Hiroki.

[4]Protective effects of Lycium barbarum polysaccharides against carbon tetrachloride-induced hepatotoxicity in precision-cut liver slices in vitro and in vivo in common carp (Cyprinus carpio L.). Liu, Yingjuan,Jia, Rui,Wang, Jiahao,Yin, Guojun,Cao, Liping,Du, Jinliang,Xu, Pao,Yin, Guojun,Cao, Liping,Du, Jinliang,Xu, Pao,Yin, Guojun. 2015

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