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Intergenerational inheritance of quercetin-induced abnormal immunity in mice

文献类型： 外文期刊

作者： Zheng, Xuanyu 1 ; Huang, Wenqi 2 ; Farag, Mohamed A. 3 ; Xiao, Jianbo 1 ; Li, Chunlin 5 ;

作者机构： 1.Jinan Univ, Coll Life Sci & Technol, Guangzhou, Peoples R China

2.Univ Virgo, Inst Agroecoloxia Alimentac IAA, Dept Analyt Chem & Food Sci, CITEXVI,Nutr & Bromatol Grp, Vigo, Spain

3.Cairo Univ, Fac Pharm, Pharmacognosy Dept, Cairo, Egypt

4.Univ Europea Atlantico, Res Grp Food Nutr Biochem & Hlth, Santander, Spain

5.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Key Lab Informat Traceabil Agr Prod, Minist Agr & Rural Affairs China, Hangzhou 310021, Peoples R China

6.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou, Peoples R China

关键词： Quercetin; intergenerational inheritance; epigenetic; immune function; infection

期刊名称：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION （ 影响因子：8.8； 五年影响因子：12.0 ）

ISSN： 1040-8398

年卷期： 2025 年

页码：

收录情况： SCI

摘要： Quercetin, a dietary flavonol enriched in food, regulates immune-related models through epigenetic modifications. However, few studies have explored the transmission of regulatory effects across generations to the progeny. Here, we selected Escherichia coli, a conditional pathogen capable of causing gastrointestinal infections or various localized tissue and organ infections under specific conditions, as the pathogenic strain to infect mice. We provide evidence that quercetin can not only induce responsiveness changes against systemic E. coli infection in directly exposed organisms, but also in subsequent generations through the transgenerational inheritance of epigenetic traits. Both parental male mice and their progeny exhibited cellular and phenotypic changes associated with metabolic alterations. Surprisingly, the male and female progeny of mice treated with quercetin (200 mg/kg) for six weeks negatively enhanced the survival rate under systemic E. coli (1 x 108 CFU/mL) infection, concurrent with an increase in bacterial loads in the liver and spleen. Serum TNF-alpha and IL-1 beta levels significantly increased post-infection in the progeny. Our results provide the first evidence of the inheritance of immunity driven by quercetin in mammals and the attenuation of protection against bacterial infection.

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