Inhibition of xanthine oxidase by copper-gallate coordination polymers and its mechanistic study
文献类型： 外文期刊
作者： Shen, Xiaoyu 2 ; Mo, Yejian 1 ; Ren, Jian 1 ; Liu, Kexin 2 ; Sun, Shili 1 ; Deng, Chunlin 2 ;
作者机构： 1.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Prov Key Lab Tea Plant Resources Innovat, Guangzhou 510640, Peoples R China
2.South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Peoples R China
3.Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Peoples R China
关键词： Hyperuricemia; Metal-polyphenol coordination polymers; Xanthine oxidase inhibitors; Antioxidant properties
期刊名称：JOURNAL OF MOLECULAR STRUCTURE （ 影响因子：4.7； 五年影响因子：4.0 ）
ISSN： 0022-2860
年卷期： 2025 年 1346 卷
页码：
收录情况： SCI
摘要： Hyperuricemia (HUA) is a metabolic disease caused by elevated uric acid levels, with xanthine oxidase (XOD) as the key enzyme in uric acid production. Current treatments primarily use XOD inhibitors (e.g., allopurinol and febuxostat), but their lack of antioxidant activity limits their ability to counteract oxidative stress in HUA. Gallic acid (GA), a polyphenol with antioxidant properties, weakly inhibits XOD but is insufficient alone. Transition metal ions like Cu2* are potent reversible XOD inhibitors, yet excessive concentrations cause toxicity. The coordination reaction effectively reduces metal ion toxicity while partially preserving the inherent antioxidant properties of polyphenols. Using gallic acid (GA) as a ligand with Cu2*, we synthesized Cu-GA complex, which forms a stable coordination polymer that minimally releases free Cu2* in water. Cu-GA demonstrated superior XOD inhibition compared to allopurinol (AP), GA, and Cu2* alone, functioning as a reversible inhibitor to reduce uric acid levels. Additionally, it maintained significant antioxidant activity while showing substantially lower cytotoxicity in LO2 and AML12 cells than free Cu2*. In conclusion, for Cu-GA, the coordination reaction retained the inhibitory effect of Cu2+ on XOD, while conferring some antioxidant effects, and also reduced the biotoxicity of Cu2+.
- 相关文献
作者其他论文 更多>>
-
Mechanism of Green Tea Peptides in Lowering Blood Pressure and Alleviating Renal Injury Induced by Hypertension Through the Ang II/TGF-β1/SMAD Signaling Pathway
作者：Li, Lulu;Li, Dongli;Li, Lulu;Sun, Shili;Lai, Xingfei;Li, Qiuhua;Chen, Ruohong;Zhang, Zhenbiao;Hao, Mengjiao;Zhang, Suwan;Sun, Lingli;Li, Dongli
关键词：tea polypeptide; hypertension; renal injury; TGF-beta/Smad signaling
-
Metabolomics-based analysis of the effects of differences in soluble sugars on the sweetness quality of six major tea types in China
作者：Li, Wen;Chen, Zhongzheng;Zhang, Zhenbiao;Chen, Ruohong;Sun, Lingli;Lai, Xingfei;Li, Qiuhua;Hao, Mengjiao;Zhang, Suwang;Sun, Shili;Li, Qian
关键词：
-
Effects of Pile-Fermentation Duration on the Taste Quality of Single-Cultivar Large-Leaf Dark Tea: Insights from Metabolomics and Microbiomics
作者：Yang, Wanying;Ni, He;Chen, Ruohong;Sun, Lingli;Li, Qiuhua;Lai, Xingfei;Zhang, Zhenbiao;Lai, Zhaoxiang;Hao, Mengjiao;Sun, Shili;Li, Qian;Lin, Sen
关键词：dark tea; quality; taste; pile-fermentation; metabolomics; microbiomics
-
Analysis of volatile metabolites and differences in aroma quality of green tea, black tea and oolong tea prepared from highly aromatic tea variety (Dancong)
作者：Zhang, Suwan;Xia, Hongling;Sun, Shili;Ma, Chenying;Pan, Shunshun;Zhang, Zhenbiao;Lai, Xingfei;Li, Qiuhua;Hao, Mengjiao;Sun, Lingli;Chen, Ruohong;Zhang, Suwan;Xia, Hongling;Sun, Shili;Ma, Chenying;Pan, Shunshun;Zhang, Zhenbiao;Lai, Xingfei;Li, Qiuhua;Hao, Mengjiao;Sun, Lingli;Chen, Ruohong;Li, Feng;Ma, Chenying
关键词：Fermentation degree; Tea; Aroma; VOCs; GC-MS
-
Low-Dose, Post-Storage Dancong Tea Attenuates Hydroalcohol-Induced Gastric Damage via Modulation Antioxidant and Anti-Inflammatory Pathways
作者：Jian, Huanwei;Chen, Zhongzheng;Chen, Ruohong;Sun, Lingli;Li, Qiuhua;Cao, Junxi;Lai, Xingfei;Zhang, Zhenbiao;Zhang, Suwan;Hao, Mengjiao;Sun, Shili
关键词：gastric injury; new tea; stored tea; low-dose; inflammatory; antioxidant
-
Effects of fermentation duration on the flavour quality of large leaf black tea based on metabolomics
作者：Dong, Haiyu;Li, Yonghui;Wang, Baijuan;Liu, Xiaohui;Lai, Xingfei;Hao, Mengjiao;Sun, Lingli;Li, Qiuhua;Chen, Ruohong;Sun, Shili;Zhang, Zhenbiao;Li, Qian
关键词：Black tea; Fermentation; Taste quality; Composition; Metabolomics
-
Piezoelectric dual network dressing with adaptive electrical stimulation for diabetic infected wound repair via antibacterial, antioxidant, anti-inflammation, and angiogenesis
作者：Ren, Jian;Wang, Xinru;Bao, Tianjing;Shen, Xiaoyu;Yin, Dongyue;Deng, Chunlin;Ren, Jian;Wang, Xinru;Bao, Tianjing;Xiao, Cairong;Deng, Chunlin;Shen, Xiaoyu;Yin, Dongyue;Deng, Chunlin;Liang, Qingyou;Sun, Shili
关键词：Metal-polyphenol network; Adaptive electrical stimulation; Diabetic wound; Antibacterial; Anti-inflammatory
