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10-Hydroxydec-2-enoic acid enhances the erythrocyte membrane fluidity via interacting with phosphatidylcholine and phosphatidylethanolamine

文献类型： 外文期刊

作者： Sha, Fangfang 1 ; Yang, Peichang 1 ; Wang, Hui 2 ; Ren, Junhua 1 ; Li, Zirui 1 ; Zhang, Lu 1 ; Fan, Pei 1 ;

作者机构： 1.Henan Univ Technol, Sch Biol Engn, 100 Lianhua St, Zhengzhou 450001, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

关键词： 10-hydroxydec-2-enoic acid; erythrocyte; membrane; fluidity

期刊名称：ITALIAN JOURNAL OF FOOD SCIENCE （ 影响因子：2.6； 五年影响因子：1.6 ）

ISSN： 1120-1770

年卷期： 2023 年 35 卷 4 期

页码：

收录情况： SCI

摘要： 10-Hydroxydec-2-enoic acid (10-HDA), the unique substance in the natural food royal jelly, is an unsaturated hydroxyl fatty acid with the bio-activity to guard against cell or tissue damages. However, the relevant mechanisms still remain largely unknown. Here, using a mouse erythrocyte model, whether the fluidity of plasma membrane is influenced by 10-HDA was investigated. 10-HDA was shown to enhance the erythrocyte membrane fluidity and to rescue the fluidity from center dot OH toxicity. In such occasions, 10-HDA promoted the dissolved O2 level in erythro-cyte suspension thereof. The levels of beta-actin and band 4.1 protein were not affected by 10-HDA in erythrocytes. In the framework of density functional theory, 10-HDA may interact with phosphatidylcholine and phosphatidy-lethanolamine, the major components of membrane lipid bilayer. This was evidenced by the fact that 10-HDA was detectable in erythrocytes after its addition to the erythrocyte suspension. Moreover, the fluorescent intensity of erythrocytes stained by the membrane probe DiIC18(5) increased with 10-HDA treatment. Hence, 10-HDA could regulate the erythrocyte membrane fluidity and the release of O2 from erythrocytes via targeting lipids rather than proteins. Our data cast light on the elucidation of the mechanism of 10-HDA modulating cell functionality and the utilization of 10-HDA in remedying the erythrocyte membrane fluidity-associated symptoms.

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