Genome-wide association research on the reproductive traits of Qianhua Mutton Merino sheep
文献类型： 外文期刊
作者： Li, Jiarong 1 ; Sun, Limin 2 ; Sun, Jiazhi 3 ; Jiang, Huaizhi 1 ;
作者机构： 1.Jilin Agr Univ, Coll Anim Sci & Technol, Changchun 130000, Peoples R China
2.Inst Anim Husb & Vet, Jilin Acad Agr Sci, Northeast Agr Res Ctr China, Changchun 130000, Peoples R China
3.Anhua Agr Insurance Co Ltd, Changchun Cent Branch, Changchun 130000, Peoples R China
关键词： Genome Analysis; Reproductive Traits; Sheep Breeds
期刊名称：ANIMAL BIOSCIENCE （ 影响因子：2.5； 五年影响因子：2.8 ）
ISSN： 2765-0189
年卷期： 2024 年 37 卷 9 期
页码：
收录情况： SCI
摘要： Objective: Qianhua Mutton Merino sheep is a new breed of meat wool sheep cultivated independently in China. In 2018, it was approved by the state and brought into the national list of livestock and poultry genetic resources. Qianhua Mutton Merino sheep have the common characteristics of typical meat livestock varieties with rapid growth and development in the early stage and high meat production performance. The objective of this research is to investigate the Genome-wide association of the reproductive traits of Qianhua Mutton Merino sheep. Methods: Qianhua Mutton Merino sheep from the breeding core group were selected as the research object, genome-wide association analysis was conducted on genes associated with the reproductive traits (singleton or twins, birth weight, age [in days] for sexual maturity, weaning weight, and daily gain from birth to weaning) of Qianhua mutton merino. Results: Our study findings showed that 151 loci of single-nucleotide polymorphisms (SNPs) were detected, among which 3 SNPs related to birth weight and weaning weight occupied a significant portion of the wide genome. The candidate genes preliminarily obtained were SYNE1, , SLC12A4, , BMP2K, , CAMK2D, , IMMP2L, , DMD, , and BCL2. Conclusion: We found 151 SNP loci for five traits related to reproduction (including singleton or twins, birth weight, age [in days] at sexual maturity, weaning weight, and daily weight gain from birth to weaning). The functions of these candidate genes were mainly enriched in nucleotide metabolism, metal ion binding, oxytocin signaling pathway, and neurotrophin signaling pathway.
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