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Stable isotope characterization of tobacco products: A determination of synthetic or natural nicotine authenticity

文献类型： 外文期刊

作者： Han, Shulei 1 ; Cui, Lili 1 ; Chen, Huan 1 ; Fu, Ya'ning 1 ; Hou, Hongwei 1 ; Hu, Qingyuan 1 ; Yuan, Yuwei 3 ;

作者机构： 1.China Natl Tobacco Qual Supervis & Test Ctr, Zhengzhou, Peoples R China

2.Key Lab Tobacco Biol Effects, Zhengzhou, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Key Lab Informat Traceabil Agr Prod, Minist Agr & Rural Affairs China, Hangzhou, Peoples R China

4.China Natl Tobacco Qual Supervis & Test Ctr, Zhengzhou 450001, Peoples R China

期刊名称：RAPID COMMUNICATIONS IN MASS SPECTROMETRY （ 影响因子：2.0； 五年影响因子：2.1 ）

ISSN： 0951-4198

年卷期： 2023 年 37 卷 3 期

页码：

收录情况： SCI

摘要： Rationale"Tobacco-free" or synthetic nicotine products have appeared in some markets, increasing potential health risks and regulatory compliance challenges. Currently, there are few reliable methods for the determination of authenticity of natural and synthetic nicotine. Analytical techniques based on stable isotopes have broad application prospects in the traceability and identification of agricultural products. MethodsTobacco leaves from four main tobacco production regions in China and different types of tobacco products were extracted with n-hexane and 5% sodium hydroxide to obtain nicotine extracts. Subsequent stable isotope mass spectrometry was performed by analyzing delta H-2, delta C-13, and delta N-15 values of nicotine. ResultsFirstly, results from a batch of 233 samples indicated stable isotopes were closely related to climate and geographical locations and provide a basis for a determination of the origin of tobacco leaves. In addition, the delta H-2 values had significant differences between natural and synthetic nicotine and the results indicate a delta H-2 value of -163.0 parts per thousand could be the threshold for assessing synthetic and natural nicotine. Finally, a total of 239 results further validated the delta H-2 value as a metric for source authentication of commercial tobacco products. ConclusionsSynthetic (S)-(-)-nicotine could be accurately and quickly identified using the method developed by measuring delta H-2 values in a qualitative manner. To our knowledge, this is the first time a stable isotope mass spectrometry technique has been used for distinguishing the source of nicotine. This technique will aid in the accurate identification, labelling, and regulation of synthetic nicotine-based tobacco products.

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