Effects of polysaccharides from bee collected pollen of Chinese wolfberry on immune response and gut microbiota composition in cyclophosphamide-treated mice
文献类型： 外文期刊
作者： Zhao, Ya 1 ; Yan, Yamei 2 ; Zhou, Wangting 1 ; Chen, Dan 1 ; Huang, Kaiyin 1 ; Yu, Shijie 1 ; Mi, Jia 2 ; Lu, Lu 2 ; Zeng, Xiaoxiong 1 ; Cao, Youlong 2 ;
作者机构： 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China
2.Natl Wolfberry Engn Res Ctr, Yinchuan 750002, Ningxia, Peoples R China
关键词： Bee collected pollen; Chinese wolfberry; Polysaccharide; Gut microbiota; Immunoregulation
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.223； 五年影响因子：5.178 ）
ISSN： 1756-4646
年卷期： 2020 年 72 卷
页码：
收录情况： SCI
摘要： The gut microbiota has emerged as an important contributor to the immune system and it is believed to be regulated by dietary fiber. In this study, therefore, the immunomodulatory and gut microbiota modulatory effects of polysaccharides from bee collected pollen of Chinese wolfberry (WBPPS) in cyclophosphamide (CTX)-treated mice were investigated. The results showed that WBPPS could enhance thymus and spleen indices and promote production of immune-related cytokines (IgA, TNF-alpha, TGF-beta 1 and IL-10) in serum of CTX-treated mice. In addition, WBPPS could significantly improve hepatic function and oxidative stress in CTX-treated mice via increasing the levels of GSH, SOD and CAT and decreasing the levels of ALT and MDA. More importantly, WBPPS remarkably increased the relative abundances of Family_XIII, Ruminococcaceae and Saccharimonadaceae while decreased the relative abundances of Tannerellaceae, Marinifilaceae and Rikenellaceae, which were closely associated with immune traits. Overall, WBPPS might be developed as a promising immunomodulator in functional foods.
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