文献类型： 外文期刊

作者： Sarker, Md Touhiduzzaman ¹ ; Wang, Shenglin ¹ ; Wang, Shuang ¹ ; Xia, Weiguang ⁷ ; Zhang, Yanan ¹ ; Jin, Chenglong ¹ ; Huang, Xuebing ¹ ; Li, Kaichao ¹ ; Elokil, Abdelmotaleb ¹ ; Lv, Yantai ⁷ ; Zheng, Chuntian ¹ ; Chen, Wei ¹ ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Peoples R China

2.State Key Lab Livestock & Poultry Breeding, Guangzhou 510640, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangzhou 510640, Peoples R China

4.Guangdong Publ Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China

5.Guangdong Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China

6.Benha Univ, Fac Agr, Dept Anim Prod, Moshtohor 13736, Egypt

7.Zhongkai Univ Agr & Engn, Innovat Inst Anim Hlth Breeding, Coll Anim Sci & Technol, Guangzhou 510225, Peoples R China

关键词： Antioxidant; Growing layer chicken; Heat stress; Intestine integrity; Sodium butyrate

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.6； 五年影响因子：2.7 ）

ISSN：

年卷期： 2025 年 21 卷 1 期

页码：

收录情况： SCI

摘要： Background This study was conducted to evaluate the effects of dietary sodium butyrate (SB) supplementation on the antioxidant status, intestinal morphology, functional damage, and barrier integrity of heat-stressed Hy-Line Sonia (HYS) layer chicks. A total of 240 female HYS at 35 days of age with average body weights (415 +/- 35 g) were divided into 6 groups with 10 replicates/group and 4 chickens per replicate. A 2 x 3 factorial design study was performed, including two conditions of ambient temperature (25 degrees C and 35 degrees C) and three dietary levels of SB (0, 0.5, and 1.0 SB g/kg diet). Results HS decreased (P < 0.05) the performance parameters final body weight (FBW), average daily gain (ADG), and average daily feed intake (ADFI), and increased mortality; compared with the HS groups, supplementation with SB decreased mortality. Compared with thermoneutral conditions, the high-temperature conditions significantly decreased (P < 0.05) the thymus, liver, and heart weights, and the relative length of the jejunum, ileum, and cecum, whereas supplementation with 0.5 SB g/kg diet increased (P < 0.05) the weight of the spleen in growing layer chickens. High temperature decreased (P < 0.05) the villus height (VH) and VH/CD ratio, and increased the crypt depth (CD), and supplementation with SB and the T x SB interaction produced greater VH and VH/CD values in the LSB2 and HSB2 groups. SB decreased (P < 0.05) the concentration of serum malondialdehyde (MDA); however, high temperature decreased (P < 0.05) the activities of the catalase (CAT) and glutathione peroxidase (GSH-Px) antioxidant enzymes. The relative mRNA expression levels of the occluding, zonula occludens-1 (ZO-1), claudin-1, and interleukin-10 (IL-10) proteins were downregulated (P < 0.05) at high-temperatures, while that of transforming growth factor-beta (TGF beta) was upregulated. Dietary supplementation decreased the expression of the inflammatory cytokines nuclear factor kappa B (NF-kappa B), transforming growth factor-beta (TGF beta), and interferon-gamma (IFN gamma), and the T x SB interaction decreased TGF beta gene expression in the LSB2 and HSB2 groups compared with that in the other groups of growing layer chickens. Conclusion SB supplementation effectively alleviated HS-induced oxidative stress and structural and functional damage to the intestine in layer chickens in the growing phase.