Integration of metagenomic and metabolomic insights into the effects of microcystin-LR on intestinal microbiota of Litopenaeus vannamei
文献类型： 外文期刊
作者： Duan, Yafei 1 ; Xing, Yifu 1 ; Zeng, Shimin 3 ; Dan, Xueming 3 ; Mo, Zequan 3 ; Zhang, Jiasong 1 ; Li, Yanwei 3 ;
作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploit, Minist Agr & Rural Affairs,Guangdong Prov Key Lab, Guangzhou, Peoples R China
2.Sanya Trop Fisheries Res Inst, Key Lab Efficient Utilizat & Proc Marine Fishery, Sanya, Peoples R China
3.South China Agr Univ, Univ Joint Lab Guangdong Prov Hong Kong & Macao R, Coll Marine Sci, Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China
关键词： shrimp; microcystin-LR; intestinal microbial; gene function; metabolites
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）
ISSN：
年卷期： 2022 年 13 卷
页码：
收录情况： SCI
摘要： Microcystin-LR (MC-LR) is a hazardous substance that threaten the health of aquatic animals. Intestinal microbes and their metabolites can interact with hosts to influence physiological homeostasis. In this study, the shrimp Litopenaeus vannamei were exposed to 1.0 mu g/l MC-LR for 72h, and the toxic effects of MC-LR on the intestinal microbial metagenomic and metabolomic responses of the shrimp were investigated. The results showed that MC-LR stress altered the gene functions of intestinal microbial, including ABC transporter, sulfur metabolism and riboflavin (VB2) metabolism, and induced a significant increase of eight carbohydrate metabolism enzymes. Alternatively, intestinal metabolic phenotypes were also altered, especially ABC transporters, protein digestion and absorption, and the biosynthesis and metabolism of amino acid. Furthermore, based on the integration of intestinal microbial metagenomic and metabolome, four bacteria species (Demequina globuliformis, Demequina sp. NBRC 110055, Sphingomonas taxi and Sphingomonas sp. RIT328) and three metabolites (yangonin, alpha-hederin and soyasaponin ii) biomarkers were identified. Overall, our study provides new insights into the effects of MC-LR on the intestinal microbial functions of L. vannamei.
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