Vasorelaxant effect of 5,7,4 '- Trihydroxyflavanone (Naringenin) via endothelium dependent, potassium and calcium channels in Sprague Dawley rats: Aortic ring model
文献类型： 外文期刊
作者： Tan, Chu Shan 1 ; Tew, Wan Yin 1 ; Chen Jingying 2 ; Yam, Mun Fei 1 ;
作者机构： 1.Fujian Univ Tradit Chinese Med, Coll Pharm, 1 Qiuyang Rd, Fuzhou 350122, Fujian, Peoples R China
2.Fujian Acad Agr Sci, Res Ctr Med Plant, Inst Agr Bioresource, Fuzhou 350003, Fujian, Peoples R China
3.Univ Sains Malaysia, Sch Pharmaceut Sci, Minden 11800, Penang, Malaysia
关键词： Naringenin; Flavonoids; Vasorelaxation; Aortic ring assay; Calcium and potassium channels
期刊名称：CHEMICO-BIOLOGICAL INTERACTIONS （ 影响因子：5.194； 五年影响因子：4.611 ）
ISSN： 0009-2797
年卷期： 2021 年 348 卷
页码：
收录情况： SCI
摘要： Naringenin is a naturally occurring flavanone (flavonoid) known to have bioactive effects on human health. It has been reported to show cardiovascular effects. This study aimed to investigate the possible vasorelaxant effect of naringenin and the mechanism behind it by using a Sprague Dawley rat aortic ring assay model. Naringenin caused significant vasorelaxation of endothelium-intact aortic rings precontracted with phenylephrine (pD2 = 4.27 +/- 0.05; Rmax = 121.70 +/- 4.04%) or potassium chloride (pD2 = 4.00 +/- 0.04; Rmax = 103.40 +/- 3.82%). The vasorelaxant effect decreased in the absence of an endothelium (pD2 = 3.34 +/- 0.10; Rmax = 62.29 +/- 2.73%). The mechanisms of the vasorelaxant effect of naringenin in the presence of antagonists were also investigated. Indomethacin, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, atropine, 4-aminopyridine, N omega-nitro-L-arginine methyl ester, glibenclamide and propranolol significantly reduced the relaxation stimulated by naringenin in the presence of endothelium. Besides that, the effect of naringenin on the voltage-operated calcium channel (VOCC) in the endothelium-intact aortic ring was studied, as was intracellular Ca2+ release from the sarcoplasmic reticulum (SR) in the endothelium-denuded aortic ring. The results showed that naringenin also significantly blocked the entry of Ca2+ via the VOCC, SERCA/SOCC and suppressed the release of Ca2+ from the SR. Thus, the vasorelaxant effect shown by naringenin mostly involve the COX pathway, the endothelium-dependent pathway via NO/sGC/prostaglandin, calcium and potassium channels.
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