Effects of Dietary Lysine Levels on Growth Performance and Glycolipid Metabolism via the AKT/FoxO1 Pathway in Juvenile Largemouth Bass, Micropterus salmoides
文献类型： 外文期刊
作者： Huang, Dongyu 1 ; Liang, Hualiang 2 ; Ge, Xianping 1 ; Zhu, Jian 1 ; Li, Songlin 3 ; Wang, Yongli 4 ; Ren, Mingchun 1 ; Chen, Xiaoru 4 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Jiangsu, Peoples R China
2.Chinese Acad Fishery Sci CAFS, Freshwater Fisheries Res Ctr FFRC, Key Lab Genet Breeding Aquat Anim & Aquaculture B, Wuxi 214081, Jiangsu, Peoples R China
3.Shanghai Ocean Univ, Minist Agr & Rural Affairs Environm Ecol & Fish N, Res Ctr, Shanghai 201306, Peoples R China
4.Tongwei Co Ltd, Hlth Aquaculture Key Lab Sichuan Prov, Chengdu 610093, Peoples R China
期刊名称：AQUACULTURE NUTRITION （ 影响因子：3.781； 五年影响因子：4.074 ）
ISSN： 1353-5773
年卷期： 2022 年 2022 卷
页码：
收录情况： SCI
摘要： A 56-day feeding experiment was conducted to determine the dietary lysine requirement of juvenile largemouth bass (Micropterus salmoides) and investigate the effects of dietary lysine on growth, whole-body composition, and hepatic gene expression related to glycolipid metabolism via the AKT/FoxO1 pathway. The juveniles (17.34 +/- 0.02 g) were fed six graded lysine levels (2.11% (control), 2.56%, 2.92%, 3.33%, 3.68%, and 4.09%, dry diet). The results showed that the 3.33% dietary lysine level significantly increased the final body weight (FBW), weight gain rate (WGR), and specific growth rate (SGR) and improved the feed conversion ratio (FCR) compared with the control group. The whole-body composition was not significantly affected by dietary lysine levels, while lowest hepatic lipid contents were found in the 2.92% and 3.33% dietary lysine groups. Regarding glycolipid metabolism, compared with the control group, 3.33% dietary lysine improved the protein kinase B (AKT) and inhibited the forkhead box O1 (FoxO1), thus upregulated the pyruvate kinase (PK) mRNA levels to enhance glycolysis. Furthermore, sterol-regulatory element binding protein-1c (SREBP1c) and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) were downregulated by 3.33% dietary lysine, which caused the downregulation of lipid synthesis-related genes acetyl-CoA carboxylase-1 (ACC) and stearyl-CoA desaturase (SCD) mRNA. In addition, 3.33% dietary lysine promoted the expression of the lipolysis-related genes peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyl transferase-1 (CPT1). According to the quadratic regression analysis based on the FCR and SGR values, the optimal dietary lysine levels were estimated to be 3.03% and 3.07% of the diet (6.39% and 6.48% of dietary protein), respectively.
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